yi-zhang
Team TFS
Team TFS
since ‎06-07-2021
‎01-16-2023

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Multi-Attribute Method (MAM): A Biopharmaceutical Basics Overview

01-16-2023
This is the second blog post in the Biopharmaceutical Basics series. The ultimate goal of biopharmaceutical development and manufacturing is to deliver the highest-quality product at the lowest cost — in the shortest time possible. However, large mol...

Simplifying mRNA 5’ Cap Characterization

08-10-2022
Why is the 5’ capping important? The 5’ cap of mRNA plays multiple key biological functions: regulation of nuclear export, prevention of degradation by exonucleases, and promotion of translation. To ensure in vivo stability and efficient protein synt...

What’s your biggest challenge in characterizing mRNA therapeutics?

06-16-2022
There’s currently significant demand for the development of new and improved analytical methods for the characterization of mRNA therapeutics. Check out my blog on an end-to-end LC-MS workflow that enables direct sequence mapping of mRNA and share yo...

Overcoming challenges with large RNA and mRNA therapeutics

06-16-2022
How mass spectrometry enables direct characterization and sequence mapping through an automated, high-throughput workflow As demonstrated by the development of the COVID-19 vaccine, large RNA (including mRNA) has emerged as a new class of therapeutic...

Understand Your Lipid Nanoparticle Composition with a Universal Detector

03-24-2022
Charged aerosol detection has been adopted as the standard technology for COVID-19 vaccine release assays at both Moderna and Pfizer/BioNTech. Check out my blog on a recent application note that describes a simple UHPLC-CAD method for the characteriz...
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