This is the second blog post in the Biopharmaceutical Basics series. The
ultimate goal of biopharmaceutical development and manufacturing is to
deliver the highest-quality product at the lowest cost — in the shortest
time possible. However, large mol...
Why is the 5’ capping important? The 5’ cap of mRNA plays multiple key
biological functions: regulation of nuclear export, prevention of
degradation by exonucleases, and promotion of translation. To ensure in
vivo stability and efficient protein synt...
There’s currently significant demand for the development of new and
improved analytical methods for the characterization of mRNA
therapeutics. Check out my blog on an end-to-end LC-MS workflow that
enables direct sequence mapping of mRNA and share yo...
How mass spectrometry enables direct characterization and sequence
mapping through an automated, high-throughput workflow As demonstrated
by the development of the COVID-19 vaccine, large RNA (including mRNA)
has emerged as a new class of therapeutic...
Charged aerosol detection has been adopted as the standard technology
for COVID-19 vaccine release assays at both Moderna and Pfizer/BioNTech.
Check out my blog on a recent application note that describes a simple
UHPLC-CAD method for the characteriz...