In this webinar, Hans Mol (RIKILT - Wageningen UR) discusses how the Thermo Scientific™ Q Exactive™ family of mass spectrometers (namely the Thermo Scientific™ Q Exactive™ Focus MS) enables their team to integrate the two approaches in one measurement and how this makes their workflow more efficient and more effective. Different non-target acquisition options of the instrument will be explained and why they favour the combination of full scan and vDIA (variable Data Independent Acquisition) for their application. The outcome of a quantitative and qualitative performance evaluation according to the EU guidelines for validation and AQC (SANCO/12571/2013) will be presented to demonstrate that this new technology is fit-for-purpose.