Optimizing LC-MS Methods for Oligonucleotide Analysis

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Optimizing LC-MS Methods for Oligonucleotide Analysis

Team TFS
Team TFS

Liquid Chromatography-Mass Spectrometry (LC-MS) assays have been one of the main choices for oligonucleotide analysis because it is possible to quantify and identify the oligonucleotide and its impurities in a single analysis.


Each stage of the analysis is important for accurate, reliable data. This presentation will discuss each stage of the analysis and focus on tuning, key parameters, and method optimization. The technology covered will be:

  • Liquid Chromatography and ion-pair reversed-phase (IPRP) chromatography columns
  • High-resolution accurate mass (HRAM) Orbitrap (MS1 and MS2 level quantitation)
  • Thermo Scientific Biopharma Finder software demonstrating the complete toolset for oligonucleotide characterization.

Who should attend?

  • Analytical Scientist
  • Method Development Specialists
  • Lab Managers

Register here

Version history
Last update:
‎08-23-2022 09:00 AM
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