Scientific Library

Looking for higher sensitivity from MC-ICP-MS?

Are you a multi-user MC-ICP-MS lab? Have you found that you are occasionally limited in your research by the technology in your lab? Or have you suffered setbacks from instrument downtime? The Thermo ScientificTM NeomaTM MC-ICP-MS system represents t...

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Determining Elemental Impurities in Pharmaceutical Products and Dietary Supplements

As we approach the point at which new USP and ICH methodologies for assessing metal contamination come into effect, companies need to act now or risk being left behind. This primer is intended to help pharmaceutical manufacturers and contract laborat...

Results of Using Re-washed Vials and Closures

This note shows that this cleaning is causing both physical damage to the glass vials and is also ineffective at removing contamination from the vial surface. This contamination is unpredictable and produces interference peaks in both LC and GC chrom...

Identification and quantification of arsenolipids using reversed-phase HPLC coupled simultaneously to high-resolution ICPMS and high-resolution electrospray MS without species-specific standards

Amayo KO, Petursdottir A, Newcombe C, Gunnlaugsdottir H, Raab A, Krupp EM, Feldmann J.Anal Chem. 2011 May 1;83(9):3589-95.Although it has been known for decades that arsenic forms fat-soluble arsenic compounds, only recent attempts to identify the co...

Identification in human urine and blood of a novel selenium metabolite, Se-methylselenoneine, a potential biomarker of metabolization in mammals of the naturally occurring selenoneine, by HPLC coupled to electrospray hybrid linear ion trap-orbital ion trap MS

Klein M, Ouerdane L, Bueno M, Pannier F.Metallomics. 2011 May 1;3(5):513-20.Speciation analysis of selenium in human urine allowed for the first time the identification of a novel selenium metabolite, Se-methylselenoneine. Despite a concentration at ...

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESIMS analysis of a new drug in development

Cuyckens F, Balcaen LI, De Wolf K, De Samber B, Van Looveren C, Hurkmans R, Vanhaecke F.Anal Bioanal Chem. 2008 Apr;390(7):1717-29. A combination of inductively coupled plasma mass spectrometry (ICP-MS) and electrospray ionization mass spectrometry (...