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Knowledge Base Articles

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.

Chow JD, Lawrence RT, Healy ME, Dominy JE, Liao JA, Breen DS, Byrne FL, Kenwood BM, Lackner C, Okutsu S, Mas VR, Caldwell SH, Tomsig JL, Cooney GJ, Puigserver PB, Turner N, James DE, Villén J, Hoehn KL.Mol Metab. 2014 Mar 12;3(4):419-31. doi: 10.1016...

The novel human β-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss.

Yu H, Dong J, Gu Y, Liu H, Xin A, Shi H, Sun F, Zhang Y, Lin D, Diao H.J Biol Chem. 2013 Apr 26;288(17):12270-82. doi: 10.1074/jbc.M112.411884. Epub 2013 Mar 12.Lipopolysaccharide (LPS) is an important pathological factor involved in serious inflamma...

Detection of Stanozolol Glucuronides in Human Sports Drug Testing by Means of High-Resolution, Accurate-Mass Mass Spectrometry

Schänzer W, Guddat S, Thomas A, Opfermann G, Geyer H, Thevis MAN-613To demonstrate the utility of direct dilute-and-shoot analysis of glucuronic acid conjugates of stanozolol by means of liquid chromatography and high-resolution, accurate-mass mass s...

Quantitation of Opiates to Low ng/mL Levels in Urine for Forensic Use Using an Affordable, High-Resolution, Accurate-Mass Mass Spectrometer

Van Natta K, Kozak MAN-615To evaluate the performance of the Thermo Scientific™ Q Exactive™ Focus hybrid quadrupole-Orbitrap™ mass spectrometer as a quantitative platform for HPLC-MS analysis of opiates in human urine to low ng/mL levels for forensic...

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