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Knowledge Base Articles

Detecting Stable Isotope Labeled Metabolites in Untargeted Analysis Using a Benchtop Orbitrap Mass Spectrometer and a Single Processing Software Platform

Amanda Souza, Ioanna Ntai, Tatjana Talamantes and Ralf TautenhahnPurpose: Develop an integrated mass spectrometry-based workflow for stable isotope labeling (SIL) in untargeted metabolomics covering data acquisition and analysis in a single experimen...

Increased throughput and coverage for the annotation of saponins using a structure-based MSn approach on an Orbitrap Tribrid mass spectrometer

Reiko Kiyonami, Caroline Ding, Seema Sharma, and Andreas HuhmerAPPLICATION NOTE 73236To develop a structure-based MSn workflow to collect more structurally relevant fragment ion information for the annotation of saponins from traditional Chinese medi...

Detecting low abundant endogenous cardiac steroids from biological fluids using a structure-based MSn approach on an Orbitrap Tribrid mass spectrometer

Reiko Kiyonami1 , Michael G. Harrington2 , Alfred N. Fonteh2 , Roger G. Biringer3 , and Andreas F. Huhmer1APPLICATION NOTE 73235To develop an unbiased discovery-to-targeted-verification approach to detect low abundant endogenous cardiac steroids from...

Metabolomics as a Discovery Tool for Bioprospecting and Detection of Defense Compounds During Fungal Infection of Spruce Wood

Marit Almvik1, Marie-Pierre Pavageau, Nina Elisabeth Nagy2, Hans Ragnar Norli1, Ari Hietala2, Sven-Roar Odenmarck1, Monica Fongen3, Anas Kamleh4 Metabolomics 2019Every fourth tree in the Scandinavian forest is infected with rot. Root and butt rot fun...

Increased Throughput and Coverage for the Annotation of Saponins Using a Structure-based MSn Approach on a Tribrid Orbitrap Mass Spectrometer

Reiko Kiyonami, Caroline Ding, Seema Sharma and Andreas Huhmer Metabolomics 2019Purpose: Develop a structure-based MSn workflow to collect more structurally relevant fragment ion information for the annotation of saponins from traditional Chinese med...

A complete workflow for improved untargeted metabolome annotation and identification using ultra high-resolution accurate mass and LC-MSn Orbitrap-based mass spectrometry

David A. Peake, Reiko Kiyonami, Ioanna Ntai, Amanda Souza and Ralf TautenhahnPurpose: Demonstrate confidence in metabolite annotation from ultra-high resolution LC-MS and data dependent MS2 data using a combined global semi-targeted (GST) metabolomic...

Detecting Low Abundant Endogenous Cardiac Steroids from Biological Fluids Using Structure-Based MSn Approach On an Orbitrap Tribrid Mass Spectrometer

Reiko Kiyonami1, Michael G. Harrington2, Alfred N. Fonteh2, Roger G. Biringer3 and Andreas F. Huhmer1ASMS 2019 PosterPurpose: Developing an unbiased discovery to targeted verification approach to detect low abundant endogenous cardiac steroids from b...

Accelerated unknown compound annotation with confidence: from spectra to structure in untargeted metabolomics experiments

Amanda Souza, Ioanna Ntai, and Ralf TautenhahnAPPLICATION NOTE 65362Use Thermo Scientific™ Compound Discoverer™ 3.0 software to process untargeted metabolomics for unknown compound annotation. Demonstrate the utility of analyzing multiple analytical ...

Grant application resource: Thermo Scientific Orbitrap ID-X Tribrid mass spectrometer for metabolomics, lipidomics and structural elucidation

WHITE PAPER 65364This document is intended to provide conclusive reasons to justify upgrading from a Thermo Scientific™ Q Exactive™ mass spectrometer series or earlier generation of Thermo Scientific™ Orbitrap™ Hybrid™ mass spectrometer series to a T...

Profiling and annotation of flavonoids using a product iondependent MSn data acquisition method on a Tribrid Orbitrap mass spectrometer

Reiko Kiyonami1, Iwao Sakane2, Seema Sharma1, Graeme Mcalister1, Caroline Ding1 and Andreas Huhmer1Metabolomics 2018The untargeted profiling of flavonoids provides insights into their biological functions and potential health benefits for humans. How...

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