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Knowledge Base Articles

Native Top-Down Analysis of Intact Antibodies using Multiple Dissociation Techniques on a Tribrid Quadrupole Orbitrap Linear Ion Trap Mass Spectrometer

Eugen Damoc1, Kristina Srzentić2, Romain Huguet3, Graeme McAlister3, Christopher Mullen3, Philip M Remes3, Jesse D Canterbury3, Mike Senko3, and Vlad Zabrouskov3 ASMS 2019 PosterPurpose: Evaluate the performance of the new Thermo Scientific™ Orbitrap...

Optimization of RP-LC-MS Top-down Protein Analysis on an Orbitrap Fusion Lumos Tribrid MS with the Advanced Peak Determination Algorithm

Vlad Zabrouskov1, Luca Fornelli2, Ryan Fellers2, Kristina Srzentic2, Joshua Silveira1, Helene Cardasis1, Graeme C. McAlister1, Christian Thoeing3, Derek Bailey1, Andreas Kuehn3, Mike Senko1, Shannon Eliuk1, Romain Huguet1, Neil Kelleher3 ASMS 2018Pur...

In-Depth Characterization of Intact Protein Standards Using HRAM Top Down Mass Spectrometry with Multiple MSMS Strategies

Helene Cardasis1, Romain Huguet1, Chris Mullen1, Stephane Houel1, Luca Forneli2, Rosa Viner1, Viktorija Vitkovske1, Shanhua Lin1, Seema Sharma1, Vlad Zabrouskov1, Neil Kelleher2ASMS 2017 PosterPurpose: Demonstrate unique characteristics and effective...

Profiling Of Clinically Relevant Proteoforms In Human Tears Using Chip-Based Capillary Electrophoresis Coupled To Mass Spectrometry

Daniel Lopez-Ferrer1, Romain Huguet1, Andreas Krupke1, Chien-Hsun Chen1, Aran Paulus1, Peter Raus2, Vlad Zabrouskov1, Andreas FR Huhmer1 and Peter Verhaert3ASMS 2017 PosterPurpose: Demonstrate the potential for profiling in very short times proteofor...

Profiling Of Clinically Relevant Proteoforms In Human Tears Using Chip-Based Capillary Electrophoresis Coupled To Mass Spectrometry

Daniel Lopez-Ferrer1, Romain Huguet1, Andreas Krupke1, Chien-Hsun Chen1, Aran Paulus1, Peter Raus2, Vlad Zabrouskov1, Andreas FR Huhmer1 and Peter Verhaert3ASMS 2017 PosterPurpose: Demonstrate the potential for profiling in very short times proteofor...

Profiling Of Clinically Relevant Proteoforms In Human Tears Using Chip-Based Capillary Electrophoresis Coupled To Mass Spectrometry

Daniel Lopez-Ferrer1, Romain Huguet1, Andreas Krupke1, Chien-Hsun Chen1, Aran Paulus1, Peter Raus2, Vlad Zabrouskov1, Andreas FR Huhmer1 and Peter Verhaert3ASMS 2017 PosterPurpose: Demonstrate the potential for profiling in very short times proteofor...

Profiling Of Clinically Relevant Proteoforms In Human Tears Using Chip-Based Capillary Electrophoresis Coupled To Mass Spectrometry

Daniel Lopez-Ferrer1, Romain Huguet1, Andreas Krupke1, Chien-Hsun Chen1, Aran Paulus1, Peter Raus2, Vlad Zabrouskov1, Andreas FR Huhmer1 and Peter Verhaert3ASMS 2017 PosterPurpose: Demonstrate the potential for profiling in very short times proteofor...

Improving high-throughput Top-Down proteomics using a modified hybrid quadrupole-ultra-high-field-Orbitrap mass spectrometer

Eugen Damoc1, Kyle L. Fort2, Michiel van de Waterbeemd2, Sem Tamara2, Christian Thoeing1, Erik Couzijn1, Kai Scheffler3, Tabiwang Arrey1, Alexander Harder1, Albert J. R. Heck2 and Alexander Makarov1ASMS 2017 PosterPurpose: Demonstrate improved Top-Do...

Fast Characterization Of The Proteoform Landscape In Human Tears Using Top Down Mass Spectrometry With Multiple MS/MS Strategies

Daniel Lopez-Ferrer1, Romain Huguet1, Ioanna Ntai1, David Horn1, Peter Raus2, Vlad Zabrouskov1, Andreas FR Huhmer1 and Peter Verhaert3ASMS 2017 PosterPurpose: Demonstrate the potential of top-down proteomics for mapping the proteoform diversity in th...

Profiling Of Clinically Relevant Proteoforms In Human Tears Using Chip-Based Capillary Electrophoresis Coupled To Mass Spectrometry

Daniel Lopez-Ferrer1, Romain Huguet1, Andreas Krupke1, Chien-Hsun Chen1, Aran Paulus1, Peter Raus2, Vlad Zabrouskov1, Andreas FR Huhmer1 and Peter Verhaert3ASMS 2017 PosterPurpose: Demonstrate the potential for profiling in very short times proteofor...

Pushing the leading edge in protein analysis: Thermo Scientific Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer

BrochureUnderstanding biomolecules as drug targets, disease markers, and therapeutic agents demands highly sensitive analysis of complex biological samples, without sacrificing robustness and speed. The Thermo Scientific™ Q Exactive™ HF-X hybrid quad...

Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer

Luca Fornelli a,1 , Daniel Ayoub a,2 , Konstantin Aizikov b , Xiaowen Liu c,d , Eugen Damoc b , Pavel A. Pevzner e , Alexander Makarov b , Alain Beck f , Yury O. Tsybin a,g, ⁎Journal of Proteomics Available online 27 February 2017The increasing impor...

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