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Knowledge Base Articles

Real-time, High Density Monitoring of pTyr Signaling Targets in Human Tumors Using Heavy Peptide Triggered Targeted Quantitation

Aaron S. Gajadhar1, Lauren E. Stopfer2, Cameron T. Flower2, Forest M. White2, Bhavin Patel3, Sebastien Gallien4, Romain Huguet1, Graeme McAlister1, Derek Bailey1, Shannon Eliuk1, Markus Kellmann5, Tabiwang N. Arrey5, Alexander Harder5, Daniel Lopez-F...

Quantitative, comprehensive multi-pathway signaling analysis using an optimized phosphopeptide enrichment method combined with an internal standard triggered targeted MS assay

Bhavin Patel1; Penny Jensen1; Aaron S. Gajadhar2; Sebastien Gallien3; Jae Choi1; Romain Huguet2; Graeme McAlister2; Derek Bailey2; Shannon Eliuk2; Markus Kellmann4; Tabiwang N. Arrey4; Alexander Harder4; Andreas Huhmer2; Kay Opperman1; John C Rogers1...

Advancing Mass Spectrometry-Based Large-Cohort Proteomics for Precision Medicine – An International Cancer Moonshot Multi-Site Study

Yue Xuan1, 2, N.W. Bateman3 , S.Gallien2,14, Y. Zhou15, N. Parikh3 , M. Hu15, P. Navarro1 , Y. Chen4 , A. Sickmann5 , B. Wollscheid6 , C.R. Jimenez7 , M.R. Larsen8 , H. Zhou9 , S. Liu10 , Z. Chen11 , T. Kislinger 12 , B. Crossett 13 , B. Hood3 , R. B...

Diagnosis of Ecosystem Adaptive Responses by Analysis of Hundreds of Peptide Biomarkers in the North Atlantic Ocean using Targeted Metaproteomics

Mak Saito1, Matt McIlvin1, Dawn Moran1, Luis Valentin1, Romain Huguet2, Graeme McAlister2, Shannon Eliuk2, Rod Johnson3ASMS 2017 PosterMotivation ● Ocean microbes are Earth’s life support system ● Developing Targeted metaproteomics to detect and diag...

Antibody verification by protein immunoprecipitation and mass spectrometry (IP-MS) characterizes antibody performance and identifies protein-protein interactions

Gregory K. Potts1, Bhavin Patel2, Leigh Foster2, John C. Rogers2ASMS 2017 PosterAntibodies have been adopted as investigative tools to empower research and diagnostic applications in academia and industry. In this role, antibodies have been utilized ...

Implementation of Real-Time Update for Time Scheduled Targeted Peptide Quantification (PRM) on a new Quadrupole Orbitrap Benchtop Mass Spectrometer

Christian Thoeing, Sebastien Gallien, Tabiwang Arrey, Yue Xuan, Oliver Lange, Kerstin Strupat , Markus KellmannPurpose: On-the-fly correction of scheduled retention time windows in order to allow more reliable profiling of more peptide targets Method...

Quantitative Analysis of Two Cancer Signaling Pathways Using Multiplex Immunoprecipitation and Targeted Mass Spectrometry

Bhavin Patel1, Penny Jensen1, Abid Haseeb1, Leigh Foster1, Gregory Potts2, Kay Opperman1, Rosa I Viner3, Andreas Huhmer3, John C Rogers1Introduction: The objective of this study was to determine the efficacy of multiplex IP to targeted MS (mIP-tMS) t...

Pushing the leading edge in protein analysis: Thermo Scientific Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer

BrochureUnderstanding biomolecules as drug targets, disease markers, and therapeutic agents demands highly sensitive analysis of complex biological samples, without sacrificing robustness and speed. The Thermo Scientific™ Q Exactive™ HF-X hybrid quad...

Analyses of Meldonium (Mildronate) from Blood, Dried Blood Spots (DBS), and Urine Suggest Drug Incorporation into Erythrocytes

L. Tretzel1, C. Görgens1, H. Geyer1, 2, A. Thomas1, J. Dib1, S. Guddat1, V. Pop3, W. Schänzer1, M. Thevis1, 2Int J Sports Med 2016; 37(06): 500-502https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-15823171Institute of Biochemi...

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