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How to create an optimized one-pot single-cell proteomics workflow

Today’s scientists want single-cell proteomics measurements because analyzing bulk cells can hide important biological differences. To facilitate a successful workflow with comprehensive proteome coverage and high throughput, single-cell proteomics s...

μPAC Neo HPLC columns: deeper proteomic coverage with shorter runtime

Ultrasensitive MS-based proteomics has seen remarkable breakthroughs in recent years. Improvements at different stages in the proteomics workflow have pushed sensitivity to a level that now allows scientists to successfully identify and quantify more...

SCoPE X improves on SCoPE-MS, 40% boost on Peptide IDs for Single-Cell Proteomics

A new single-cell proteomics pre-print from Juerg Straubhaar and Bogdan Budnik et al., Bogdan along with Nikolai Slavov, developed the SCoPE-MS approach for single-cell proteomics that is most commonly used at the moment on Orbitrap mass spectrometer...

Single-cell proteomics – same cell type, same amount of protein?

The number of cell types in a normal, healthy adult is estimated to be 200-400, according to Alberts et al1, Molecular Biology of the Cell, and Vickaryous et.al2, in Human Cell Diversity, as we have not been able to dissect every single cell in the h...