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Knowledge Base Articles

Pushing the leading edge in protein analysis: Thermo Scientific Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer

BrochureUnderstanding biomolecules as drug targets, disease markers, and therapeutic agents demands highly sensitive analysis of complex biological samples, without sacrificing robustness and speed. The Thermo Scientific™ Q Exactive™ HF-X hybrid quad...

Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer - The Most Powerful Instrument Designed to Advance Your Scientific Pursuits

Orbitrap Fusion Lumos MS BrochurePUSHING NEW FRONTIERS IN SCIENCE Breakthroughs in science rely on great scientists making rapid progress answering challenging questions. “How does lipid metabolism affect cancer?” “How do non-cancerous cells mutate?”...

Terminal galactosylation and sialylation switching on membrane glycoproteins upon TNF-alpha-induced insulin resistance in adipocytes

Benjamin L. Parker, Morten Thaysen-Andersen, Daniel J. Fazakerley, Mira Holliday, Nicolle H. Packer, and David E. JamesMol Cell Proteomics mcp.M115.054221. First Published on November 4, 2015, doi:10.1074/mcp.M115.054221Insulin resistance (IR) is a c...

Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis

Susanne B. Breitkopf, Min Yuan, Katja P. Helenius, Costas A. Lyssiotis and John M. AsaraAnalytical Chemistry, 2015, 87 (21), pp 10995–11006The combination of metabolomics, lipidomics, and phosphoproteomics that incorporates triple stable isotope la...

Targeted metabolomic analysis of head and neck cancer cells using high performance ion chromatography coupled with a Q Exactive HF mass spectrometer

Hu SS, Wang J, Ji EH, Christison T, Lopez L, Huang Y.Anal. Chem., 2015, 87 (12), pp 6371–6379In this study, we have demonstrated a targeted metabolomics method for analysis of cancer cells, based on high-performance ion chromatography (IC) separati...

An Integrated Platform for Isolation, Processing and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood.

Li S, Plouffe BD, Belov AM, Ray S, Wang X, Murthy SK, Karger BL, Ivanov AR.Mol Cell Proteomics. 2015 Mar 9. pii: mcp.M114.045724.Isolation and molecular characterization of rare cells (e.g. circulating tumor and stem cells) within biological fluids a...

A DNA-centric protein interaction map of ultraconserved elements reveals contribution of transcription factor binding hubs to conservation.

Viturawong T, Meissner F, Butter F, Mann M.Cell Rep. 2013 Oct 31;5(2):531-45. doi: 10.1016/j.celrep.2013.09.022. Epub 2013 Oct 17.Ultraconserved elements (UCEs) have been the subject of great interest because of their extreme sequence identity and th...

Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples.

Boersema PJ, Geiger T, Wisniewski JR, Mann M.Mol Cell Proteomics. 2013 Jan;12(1):158-71.Cells secrete a large number of proteins to communicate with their surroundings. Furthermore, plasma membrane proteins and intracellular proteins can be released ...

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