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Knowledge Base Articles

A robust mass spectrometer for precision medicine – the Orbitrap Exploris 240 mass spectrometer for large-scale plasma protein profiling

Michelle L Dubuke1 , Sitara Chauhan1 , Sarah Trusiak1 , and Emily I. Chen1APPLICATION NOTE 65952To demonstrate the reliability and robustness of the Thermo Scientific™ Orbitrap Exploris™ 240 mass spectrometer for large-scale, untargeted plasma protei...

Extending Capabilities of Real-Time Database Search on the Orbitrap Eclipse Tribrid Mass Spectrometer for Multiplexed Proteomics

Yang Liu, William D. Barshop, Amirmansoor Hakimi, Jesse D. Canterbury, Romain Huguet, Rosa Viner International Hupo 2020To evaluate recent improvements to Real-Time Search for TMT SPS MS3 quantitation workflow including: 1) Close-out to prevent acqui...

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

Dounia Djeghloul, Bhavik Patel, Holger Kramer, Andrew Dimond, Chad Whilding, Karen Brown, Anne-Céline Kohler, Amelie Feytout, Nicolas Veland, James Elliott, Tanmay A. M. Bharat, Abul K. Tarafder, Jan Löwe, Bee L. Ng, Ya Guo, Jacky Guy, Miles K. Husey...

Sensitive and High-throughput Single-cell Proteomics Workflow on New Quadrupole-ion trap-Orbitrap Mass Spectrometer with FAIMS Separation

Khatereh Motamedchaboki1; Maowei Dou1; Yongzheng Cong2; Romain Huguet1; Aaron M Robitaille1; David M Horn1; Yufeng Shen3; Daniel Lopez-Ferrer1; Ryan T Kelly2, 4; Ying Zhu4.ASMS 2020Traditionally, proteomics experiments are applied to large population...

Deep Proteome Coverage and Label-Free Proteomic Analysis of Low Numbers of Mammalian Cells with a Quadrupole-Ion trap-Orbitrap Mass Spectrometer

Min Huang, Xiujie Sun, and Yue ZhouASMS 2020Purpose: To improve the proteome coverage and label-free quantitation performance of limited number of mammalian cells. Methods: Different sample preparation methods and LC-MS parameters were compared for p...

High-throughput single cell proteomics analysis with nanodroplet sample processing, multiplex TMT labeling, and ultra-sensitive LC-MS

Khatereh Motamedchaboki1 , Maowei Dou1 , Yongzheng Cong2 , Romain Huguet1 , Aaron M Robitaille1 , Yufeng Shen3 , Geremy Clair4 ,Charles Ansong4 , Daniel Lopez-Ferrer1 , Ryan T. Kelly2,4, and Ying Zhu4APPLICATION NOTE 65714Understanding heterogeneity ...

Standardized and scalable plasma protein quantitative profiling workflow using human blood based on a Thermo Scientific Q exactive platform

Jing Wang1; Sarah Trusiak1; Ryan D. Bomgarden2; Sergei Snovida2; Michelle Dubuke1, Emily I. Chen1APLICATION NOTE No. 73194To develop a high throughput plasma and serum proteomics analysis workflow for large population cohort studies that utilizes a s...

Standardized and scalable plasma protein quantitative profiling workflow using human blood based on a Thermo Scientific Q exactive platform

Jing Wang1; Sarah Trusiak1; Ryan D. Bomgarden2; Sergei Snovida2; Michelle Dubuke1, Emily I. Chen1APLICATION NOTE No. 73194To develop a high throughput plasma and serum proteomics analysis workflow for large population cohort studies that utilizes a s...

Smart TMT with API

Qing YuASMS 2019 Orbitrap Power User MeetingA strategy to combine sample multiplexing with targeted proteomics assays for high throughput protein signature characterizationHarvard Medical School

High-Throughput Single Cell Proteomics Analysis with Nanodroplet Sample Processing, Multiplex TMT labeling, and Ultra-Sensitive LC-MS

Khatereh Motamedchaboki1, Maowei Dou1, Yongzheng Cong2, Romain Huguet1, Aaron M Robitaille1, Yufeng Shen3, Geremy Clair,4 Charles Ansong,4 Daniel Lopez-Ferrer1, Ryan T. Kelly2,4, and Ying Zhu4 Hupo 2019Understanding heterogeneity at single cell level...

Ultra-sensitive LC/MS workflow for in-depth label-free analysis of single mammalian cells with nanodroplet sample processing

Khatereh Motamedchaboki1, Yongzheng Cong2, Yiran Liang2, Romain Huguet1, Yufeng Shen3, Xuefei Sun1, Greg Foster1, Daniel Lopez-Ferrer1, Andreas F. Huhmer1, Ying Zhu4 and Ryan T. Kelly2,4Hupo 2019In the last decade, single cell RNA sequencing has adva...

Powerful, standardized and versatile low-flow LCMS platform for deep dive proteomics and high-throughput analysis with maximum MS utilization

Oleksandr Boychenko1, Christopher Pynn1, Mike Baynham2, Jenny Ho3, Tabiwang Arrey4, and Peter Jehle1Hupo 2019Purpose: The availability and ease of sampling of blood and its constituents make it ideal for large cohort clinical research studies. Protei...

Standardized and scalable plasma protein quantitative profiling workflow using human blood based on a Thermo Scientific Q exactive platform

Jing Wang1; Sarah Trusiak1; Ryan D. Bomgarden2; Sergei Snovida2; Michelle Dubuke1, Emily I. Chen1APLICATION NOTE No. 73194To develop a high throughput plasma and serum proteomics analysis workflow for large population cohort studies that utilizes a s...

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