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Knowledge Base Articles

A robust mass spectrometer for precision medicine – the Orbitrap Exploris 240 mass spectrometer for large-scale plasma protein profiling

Michelle L Dubuke1 , Sitara Chauhan1 , Sarah Trusiak1 , and Emily I. Chen1APPLICATION NOTE 65952To demonstrate the reliability and robustness of the Thermo Scientific™ Orbitrap Exploris™ 240 mass spectrometer for large-scale, untargeted plasma protei...

An Ultra High-throughput Plasma Protein Profiling (uHTPPP) Workflow Using a Modified Quadrupole-Orbitrap Mass Spectrometer

Michelle L. Dubuke1, Sarah Trusiak1, Sitara Chauhan1,Ryan D. Bomgarden2, Sergei Snovida2, Bhavin Patel2, Emily I. Chen1.An automated plasma protein profiling workflow on the new Orbitrap Exploris 240 mass spectrometer can deliver the consistency, sen...

Pushing the Limits of Sensitivity: Micropillar Array-Based Chromatography Coupled to a Quadrupole Orbitrap Mass Spectrometer and FAIMS for Low-Input Proteomics

Julia Kraegenbring1, Karel Stejskal2, Claudia Ctortecka2, Gabriela Krššáková2, Jeff Op De Beeck3, Tabiwang N. Arrey1, Bernard Delanghe1, Alexander Harder1, Karl Mechtler4ASMS 20201 Thermo Fisher Scientific, Hanna-Kunath-Str. 11, Bremen, Germany. 2 In...

Sampling the human population – ultra-highthroughput plasma protein profiling (uHTPPP) sample preparation for translational proteomics

Sarah Trusiak,1 Sergei Snovida,2 Bhavin Patel,2 Ryan Bomgarden,2 Emily I. Chen,1Present a robust, precise, and reproducible highthroughput sample preparation workflow for mass spectrometry-based large population cohort studies.1. Thermo Fisher Scient...

Reliable and Deep Proteome Coverage by Gas-Phase Fractionation of Peptides with a FAIMS Pro Interface on a Modified Quadrupole Orbitrap

Julia Kraegenbring1, Tabiwang N. Arrey1, Michael W. Belford2, Satendra Prasad2, Kerstin Strupat1, Markus Kellmann1, Thomas Moehring1, and Alexander Harder1Hupo 2019Purpose: Demonstrate the benefit of Thermo Scientific™ FAIMS Pro™ interface for proteo...

Powerful, standardized and versatile low-flow LCMS platform for deep dive proteomics and high-throughput analysis with maximum MS utilization

Oleksandr Boychenko1, Christopher Pynn1, Mike Baynham2, Jenny Ho3, Tabiwang Arrey4, and Peter Jehle1Hupo 2019Purpose: The availability and ease of sampling of blood and its constituents make it ideal for large cohort clinical research studies. Protei...

Lifting the Albumin Curtain to Increase Plasma Proteome Profiling: Incorporating Differential Ion Mobility for Increased Proteome Coverage

Scott Peterman1, Romain Huguet1, Michael Belford1, Susan Abbatiello2 ASMS 2019 PosterPurpose: Increase the plasma proteome coverage for routine profiling analysis. Methods: Incorporation of the Thermo Scientific™ FAIMS Pro™ interface with the Thermo ...

Modifying the Ion Optics and Scan Sequences on a Tribrid MS to Improve Sensitivity, Duty Cycle, and Overall Instrument Ease-of-Use

Graeme C. McAlister1, Mike Goodwin1, Raman Mathur1, Lee Earley1, Oliver Lange2, Romain Huguet1, Vlad Zabrouskov1, and Mike Senko1. ASMS 2019 PosterPurpose: We modified the ion optics on a Tribrid mass spectrometer to improve its quadrupole selectivit...

Optimized DDA+ and HR-DIA workflows for standardized, reproducible, precise and robust label-free quantitation of proteomes

Aaron S. Gajadhar1, Oleksandr Boychenko2, Xin Zhang3, Yue Xuan4, and Andreas HuhmerASMS 2018Purpose: To overcome the limitations of current label-free proteome quantitation (LFQ) protocols, we sought to develop an end-to-end, complete LFQ workflow so...

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