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Knowledge Base Articles

Expanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry

Lennart Schnirch, Michal Nadler-Holly, Siang-Wun Siao, Christian K. Frese, Rosa Viner, and Fan LiuIn cross-linking mass spectrometry (XL-MS), the depth and sensitivity of cross-link detection is often limited by the low abundance of cross-links compa...

Analysis of Therapeutic Monoclonal Antibodies Using Volatile pH Gradient Cation Exchange Chromatography Directly Coupled to Native Mass Spectrometry

Julia Baek1, Rosa Viner2, Terry Zhang2, Eugen Damoc3, Shanhua Lin1 ASMS 2019 PosterPurpose: To optimize a volatile pH gradient mobile phase system for native mass spectrometry analysis of monoclonal antibody charge variants using weak cation exchange...

Modifying the Ion Optics and Scan Sequences on a Tribrid MS to Improve Sensitivity, Duty Cycle, and Overall Instrument Ease-of-Use

Graeme C. McAlister1, Mike Goodwin1, Raman Mathur1, Lee Earley1, Oliver Lange2, Romain Huguet1, Vlad Zabrouskov1, and Mike Senko1. ASMS 2019 PosterPurpose: We modified the ion optics on a Tribrid mass spectrometer to improve its quadrupole selectivit...

Native Top-Down Analysis of Intact Antibodies using Multiple Dissociation Techniques on a Tribrid Quadrupole Orbitrap Linear Ion Trap Mass Spectrometer

Eugen Damoc1, Kristina Srzentić2, Romain Huguet3, Graeme McAlister3, Christopher Mullen3, Philip M Remes3, Jesse D Canterbury3, Mike Senko3, and Vlad Zabrouskov3 ASMS 2019 PosterPurpose: Evaluate the performance of the new Thermo Scientific™ Orbitrap...

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