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Knowledge Base Articles

A robust mass spectrometer for precision medicine – the Orbitrap Exploris 240 mass spectrometer for large-scale plasma protein profiling

Michelle L Dubuke1 , Sitara Chauhan1 , Sarah Trusiak1 , and Emily I. Chen1APPLICATION NOTE 65952To demonstrate the reliability and robustness of the Thermo Scientific™ Orbitrap Exploris™ 240 mass spectrometer for large-scale, untargeted plasma protei...

Expanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry

Lennart Schnirch, Michal Nadler-Holly, Siang-Wun Siao, Christian K. Frese, Rosa Viner, and Fan LiuIn cross-linking mass spectrometry (XL-MS), the depth and sensitivity of cross-link detection is often limited by the low abundance of cross-links compa...

An Ultra High-throughput Plasma Protein Profiling (uHTPPP) Workflow Using a Modified Quadrupole-Orbitrap Mass Spectrometer

Michelle L. Dubuke1, Sarah Trusiak1, Sitara Chauhan1,Ryan D. Bomgarden2, Sergei Snovida2, Bhavin Patel2, Emily I. Chen1.An automated plasma protein profiling workflow on the new Orbitrap Exploris 240 mass spectrometer can deliver the consistency, sen...

Pushing the Limits of Sensitivity: Micropillar Array-Based Chromatography Coupled to a Quadrupole Orbitrap Mass Spectrometer and FAIMS for Low-Input Proteomics

Julia Kraegenbring1, Karel Stejskal2, Claudia Ctortecka2, Gabriela Krššáková2, Jeff Op De Beeck3, Tabiwang N. Arrey1, Bernard Delanghe1, Alexander Harder1, Karl Mechtler4ASMS 20201 Thermo Fisher Scientific, Hanna-Kunath-Str. 11, Bremen, Germany. 2 In...

Sampling the human population – ultra-highthroughput plasma protein profiling (uHTPPP) sample preparation for translational proteomics

Sarah Trusiak,1 Sergei Snovida,2 Bhavin Patel,2 Ryan Bomgarden,2 Emily I. Chen,1Present a robust, precise, and reproducible highthroughput sample preparation workflow for mass spectrometry-based large population cohort studies.1. Thermo Fisher Scient...

Standardized and scalable plasma protein quantitative profiling workflow using human blood based on a Thermo Scientific Q exactive platform

Jing Wang1; Sarah Trusiak1; Ryan D. Bomgarden2; Sergei Snovida2; Michelle Dubuke1, Emily I. Chen1APLICATION NOTE No. 73194To develop a high throughput plasma and serum proteomics analysis workflow for large population cohort studies that utilizes a s...

Standardized and scalable plasma protein quantitative profiling workflow using human blood based on a Thermo Scientific Q exactive platform

Jing Wang1; Sarah Trusiak1; Ryan D. Bomgarden2; Sergei Snovida2; Michelle Dubuke1, Emily I. Chen1APLICATION NOTE No. 73194To develop a high throughput plasma and serum proteomics analysis workflow for large population cohort studies that utilizes a s...

Reliable and Deep Proteome Coverage by Gas-Phase Fractionation of Peptides with a FAIMS Pro Interface on a Modified Quadrupole Orbitrap

Julia Kraegenbring1, Tabiwang N. Arrey1, Michael W. Belford2, Satendra Prasad2, Kerstin Strupat1, Markus Kellmann1, Thomas Moehring1, and Alexander Harder1Hupo 2019Purpose: Demonstrate the benefit of Thermo Scientific™ FAIMS Pro™ interface for proteo...

Powerful, standardized and versatile low-flow LCMS platform for deep dive proteomics and high-throughput analysis with maximum MS utilization

Oleksandr Boychenko1, Christopher Pynn1, Mike Baynham2, Jenny Ho3, Tabiwang Arrey4, and Peter Jehle1Hupo 2019Purpose: The availability and ease of sampling of blood and its constituents make it ideal for large cohort clinical research studies. Protei...

Standardized and scalable plasma protein quantitative profiling workflow using human blood based on a Thermo Scientific Q exactive platform

Jing Wang1; Sarah Trusiak1; Ryan D. Bomgarden2; Sergei Snovida2; Michelle Dubuke1, Emily I. Chen1APLICATION NOTE No. 73194To develop a high throughput plasma and serum proteomics analysis workflow for large population cohort studies that utilizes a s...

Analysis of Therapeutic Monoclonal Antibodies Using Volatile pH Gradient Cation Exchange Chromatography Directly Coupled to Native Mass Spectrometry

Julia Baek1, Rosa Viner2, Terry Zhang2, Eugen Damoc3, Shanhua Lin1 ASMS 2019 PosterPurpose: To optimize a volatile pH gradient mobile phase system for native mass spectrometry analysis of monoclonal antibody charge variants using weak cation exchange...

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