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Knowledge Base Articles

Pushing the leading edge in protein analysis: Thermo Scientific Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer

BrochureUnderstanding biomolecules as drug targets, disease markers, and therapeutic agents demands highly sensitive analysis of complex biological samples, without sacrificing robustness and speed. The Thermo Scientific™ Q Exactive™ HF-X hybrid quad...

Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer - The Most Powerful Instrument Designed to Advance Your Scientific Pursuits

Orbitrap Fusion Lumos MS BrochurePUSHING NEW FRONTIERS IN SCIENCE Breakthroughs in science rely on great scientists making rapid progress answering challenging questions. “How does lipid metabolism affect cancer?” “How do non-cancerous cells mutate?”...

Simultaneous, Fast Analysis of Melamine and Analogues in Pharmaceutical Components Using Q Exactive - Benchtop Orbitrap LC-MS/MS

Comstock K, Stratton T, Wang J, Huang YASMS 2012 PosterPurpose: Demonstrate a simple workflow for the simultaneous analysis of melamine and analogues in pharmaceutical components using a Q Exactive benchtop Orbitrap mass spectrometer. Method: A sensi...

Impurity Analysis of Selective High Affinity Ligands: Comparison of Bench-Scale vs. Production Syntheses by Label Free Differential Analysis

Prieto Conaway MC, Sutton J, Stratton T, Wang L, Comstock K, Hok S, Balhorn R.ASMS 2012 PosterPurpose: Impurity analysis using LC-MS and differential analysis software to determine impurities between two synthetic pathways for a drug with potential i...

Limits of sensitivity - What you look for is what you'll find! The power of the Exactive, a full scan high resolution Qual/Quant mass spectrometer

Münster H, Christians U.WebinarQualitative confirmation and quantitative determinations of metabolites in biological matrices is one of the challenging analytical fields. Various methodologies are employed to meet the challenge. Metabolite research i...

Using Multiple Mass Defect Filters and Higher Energy Collisional Dissociation on an LTQ Orbitrap for Fast, Sensitive and Accurate Metabolite ID

Huang Y, Liu S, Miao S, Jeanville PM.Scientific PosterAn integral part of drug discovery and development is the identification of drug metabolites formed through phase I and phase II metabolic reactions. These metabolites may have intrinsic pharmacol...

Investigation of bioactivation of ticlopidine using linear ion trap/Orbitrap mass spectrometry and an improved mass defect filtering technique

Ruan Q, Zhu M.Chem Res Toxicol. 2010 May 17;23(5):909-17.The bioactivation of ticlopidine, a widely used antiplatelet drug, into reactive metabolites and their subsequent covalent binding to cellular macromolecules are thought to be involved in the o...

Metabolite identification in rat brain microdialysates by direct infusion nanoelectrospray ionization after desalting on a ZipTip and LTQ/Orbitrap mass spectrometry

Erve JC, Beyer CE, Manzino L, Talaat RE.Rapid Commun Mass Spectrom. 2009 Dec;23(24):4003-12.Analyzing brain microdialysate samples by mass spectrometry is challenging due to the high salt content of the artificial cerebral spinal fluid (aCSF), low an...

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