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Knowledge Base Articles

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue associated with an instrument method including data dependent MS2 triggered MS2 acquisition using UVPD activation.

Orbitrap Tribrid Series 3.4 PatchAcquisition crash can be observed with an instrument method including data dependent MS2 triggered MS2 acquisition using UVPD activation.Thermo Fisher Scientific

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue associated with possible signal intensity fluctuation under specific acquisition conditions.

Orbitrap Tribrid Series 3.4 PatchThe fluctuation in signal intensity could be observed when performing DDA acquisition with precursor ions fragmented by resonance CID activation and with MS2 spectra acquired in Orbitrap and using Auto Mass Range sett...

Orbitrap Tribrid Series 3.4 Patch: This patch works around a problem in which split peaks could be observed only after instrument bootup.

Orbitrap Tribrid Series 3.4 PatchAfter toggling instrument polarity or eFT state, or perhaps running the eFT calibration, the peak splitting goes away and does not return until the next instrument reset. This was traced to a problem with certain stag...

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue where sometimes the Trap Resonance CID calibration doesn’t reliably pass.

Orbitrap Tribrid Series 3.4 PatchIn some instances, the coarse calibration adjustment, that is automatically done behind the scenes, could make the calibration more difficult to pass, while the calibration would pass fine if this coarse adjustment wa...

Extending Capabilities of Real-Time Database Search on the Orbitrap Eclipse Tribrid Mass Spectrometer for Multiplexed Proteomics

Yang Liu, William D. Barshop, Amirmansoor Hakimi, Jesse D. Canterbury, Romain Huguet, Rosa Viner International Hupo 2020To evaluate recent improvements to Real-Time Search for TMT SPS MS3 quantitation workflow including: 1) Close-out to prevent acqui...

Expanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry

Lennart Schnirch, Michal Nadler-Holly, Siang-Wun Siao, Christian K. Frese, Rosa Viner, and Fan LiuIn cross-linking mass spectrometry (XL-MS), the depth and sensitivity of cross-link detection is often limited by the low abundance of cross-links compa...

Sensitive and High-throughput Single-cell Proteomics Workflow on New Quadrupole-ion trap-Orbitrap Mass Spectrometer with FAIMS Separation

Khatereh Motamedchaboki1; Maowei Dou1; Yongzheng Cong2; Romain Huguet1; Aaron M Robitaille1; David M Horn1; Yufeng Shen3; Daniel Lopez-Ferrer1; Ryan T Kelly2, 4; Ying Zhu4.ASMS 2020Traditionally, proteomics experiments are applied to large population...

Deep Proteome Coverage and Label-Free Proteomic Analysis of Low Numbers of Mammalian Cells with a Quadrupole-Ion trap-Orbitrap Mass Spectrometer

Min Huang, Xiujie Sun, and Yue ZhouASMS 2020Purpose: To improve the proteome coverage and label-free quantitation performance of limited number of mammalian cells. Methods: Different sample preparation methods and LC-MS parameters were compared for p...

High-throughput single cell proteomics analysis with nanodroplet sample processing, multiplex TMT labeling, and ultra-sensitive LC-MS

Khatereh Motamedchaboki1 , Maowei Dou1 , Yongzheng Cong2 , Romain Huguet1 , Aaron M Robitaille1 , Yufeng Shen3 , Geremy Clair4 ,Charles Ansong4 , Daniel Lopez-Ferrer1 , Ryan T. Kelly2,4, and Ying Zhu4APPLICATION NOTE 65714Understanding heterogeneity ...

Orbitrap Tribrid Series 3.3 Fix: Instructions are available to fix an issue with the ETD Reagent intensity on Orbitrap Fusion (only) systems.

Orbitrap Tribrid Series 3.3 ETD Fix InstructionsOrbitrap Fusion (only) ETD systems may show low (~2x) ETD reagent anion signal intensity due to a narrow tuning range of trap lens 1 (TL1), which can lead to longer than necessary reagent injection time...

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