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Knowledge Base Articles

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue associated with an instrument method including data dependent MS2 triggered MS2 acquisition using UVPD activation.

Orbitrap Tribrid Series 3.4 PatchAcquisition crash can be observed with an instrument method including data dependent MS2 triggered MS2 acquisition using UVPD activation.Thermo Fisher Scientific

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue associated with possible signal intensity fluctuation under specific acquisition conditions.

Orbitrap Tribrid Series 3.4 PatchThe fluctuation in signal intensity could be observed when performing DDA acquisition with precursor ions fragmented by resonance CID activation and with MS2 spectra acquired in Orbitrap and using Auto Mass Range sett...

Orbitrap Tribrid Series 3.4 Patch: This patch works around a problem in which split peaks could be observed only after instrument bootup.

Orbitrap Tribrid Series 3.4 PatchAfter toggling instrument polarity or eFT state, or perhaps running the eFT calibration, the peak splitting goes away and does not return until the next instrument reset. This was traced to a problem with certain stag...

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue where sometimes the Trap Resonance CID calibration doesn’t reliably pass.

Orbitrap Tribrid Series 3.4 PatchIn some instances, the coarse calibration adjustment, that is automatically done behind the scenes, could make the calibration more difficult to pass, while the calibration would pass fine if this coarse adjustment wa...

Orbitrap Tribrid Series 3.3 Patch: Access is available to disable the MS1-only experiment dynamic target adjustment algorithm, which had been implemented for 3.3.

Orbitrap Tribrid Series 3.3 Patch Access is available to disable the MS1-only experiment dynamic target adjustment algorithm, which had been implemented for 3.3. This algorithm was already being used for MS1 scans in DDA experiments, but not in MS1 o...

Orbitrap Tribrid Series 3.3 Patch: A patch is available to fix an issue with the TopN logic during MSn scans (where n>=2).

Orbitrap Tribrid Series 3.3 PatchA patch is available to fix an issue with the TopN logic during MSn scans (where n>=2). Because of a defect in our asynchronous processing of MSn scans (where n>=2), the topN counter was sometimes shared between conse...

Orbitrap Tribrid Series 3.3 Patch: This patch fixes an issue with the “High mass range Enfuvirtide : IRM to CT Transfer” calibration.

Orbitrap Tribrid Series 3.3 PatchThe unpatched version of software would try to set the pressure mode to “high” during the calibration on all instrument types. All non-Eclipse Tribrids will fail to reach this higher pressure mode (20 mTorr), and will...

Increased throughput and coverage for the annotation of saponins using a structure-based MSn approach on an Orbitrap Tribrid mass spectrometer

Reiko Kiyonami, Caroline Ding, Seema Sharma, and Andreas HuhmerAPPLICATION NOTE 73236To develop a structure-based MSn workflow to collect more structurally relevant fragment ion information for the annotation of saponins from traditional Chinese medi...

Detecting low abundant endogenous cardiac steroids from biological fluids using a structure-based MSn approach on an Orbitrap Tribrid mass spectrometer

Reiko Kiyonami1 , Michael G. Harrington2 , Alfred N. Fonteh2 , Roger G. Biringer3 , and Andreas F. Huhmer1APPLICATION NOTE 73235To develop an unbiased discovery-to-targeted-verification approach to detect low abundant endogenous cardiac steroids from...

Metabolomics as a Discovery Tool for Bioprospecting and Detection of Defense Compounds During Fungal Infection of Spruce Wood

Marit Almvik1, Marie-Pierre Pavageau, Nina Elisabeth Nagy2, Hans Ragnar Norli1, Ari Hietala2, Sven-Roar Odenmarck1, Monica Fongen3, Anas Kamleh4 Metabolomics 2019Every fourth tree in the Scandinavian forest is infected with rot. Root and butt rot fun...

Increased Throughput and Coverage for the Annotation of Saponins Using a Structure-based MSn Approach on a Tribrid Orbitrap Mass Spectrometer

Reiko Kiyonami, Caroline Ding, Seema Sharma and Andreas Huhmer Metabolomics 2019Purpose: Develop a structure-based MSn workflow to collect more structurally relevant fragment ion information for the annotation of saponins from traditional Chinese med...

Getting Connected Guide: Orbitrap Tribrid Series

This guide describes how to install the MS system in your laboratory and connect any external liquid chromatography (LC) devices. External devices include those that are controlled from or are independent of Thermo Scientific mass spectrometry applic...

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