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Knowledge Base Articles

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue associated with an instrument method including data dependent MS2 triggered MS2 acquisition using UVPD activation.

Orbitrap Tribrid Series 3.4 PatchAcquisition crash can be observed with an instrument method including data dependent MS2 triggered MS2 acquisition using UVPD activation.Thermo Fisher Scientific

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue associated with possible signal intensity fluctuation under specific acquisition conditions.

Orbitrap Tribrid Series 3.4 PatchThe fluctuation in signal intensity could be observed when performing DDA acquisition with precursor ions fragmented by resonance CID activation and with MS2 spectra acquired in Orbitrap and using Auto Mass Range sett...

Extending Capabilities of Real-Time Database Search on the Orbitrap Eclipse Tribrid Mass Spectrometer for Multiplexed Proteomics

Yang Liu, William D. Barshop, Amirmansoor Hakimi, Jesse D. Canterbury, Romain Huguet, Rosa Viner International Hupo 2020To evaluate recent improvements to Real-Time Search for TMT SPS MS3 quantitation workflow including: 1) Close-out to prevent acqui...

Sensitive and High-throughput Single-cell Proteomics Workflow on New Quadrupole-ion trap-Orbitrap Mass Spectrometer with FAIMS Separation

Khatereh Motamedchaboki1; Maowei Dou1; Yongzheng Cong2; Romain Huguet1; Aaron M Robitaille1; David M Horn1; Yufeng Shen3; Daniel Lopez-Ferrer1; Ryan T Kelly2, 4; Ying Zhu4.ASMS 2020Traditionally, proteomics experiments are applied to large population...

High-throughput single cell proteomics analysis with nanodroplet sample processing, multiplex TMT labeling, and ultra-sensitive LC-MS

Khatereh Motamedchaboki1 , Maowei Dou1 , Yongzheng Cong2 , Romain Huguet1 , Aaron M Robitaille1 , Yufeng Shen3 , Geremy Clair4 ,Charles Ansong4 , Daniel Lopez-Ferrer1 , Ryan T. Kelly2,4, and Ying Zhu4APPLICATION NOTE 65714Understanding heterogeneity ...

Orbitrap Tribrid Series 3.3 Patch: Access is available to disable the MS1-only experiment dynamic target adjustment algorithm, which had been implemented for 3.3.

Orbitrap Tribrid Series 3.3 Patch Access is available to disable the MS1-only experiment dynamic target adjustment algorithm, which had been implemented for 3.3. This algorithm was already being used for MS1 scans in DDA experiments, but not in MS1 o...

Orbitrap Tribrid Series 3.3 Patch: A patch is available to fix an issue with the TopN logic during MSn scans (where n>=2).

Orbitrap Tribrid Series 3.3 PatchA patch is available to fix an issue with the TopN logic during MSn scans (where n>=2). Because of a defect in our asynchronous processing of MSn scans (where n>=2), the topN counter was sometimes shared between conse...

High-Throughput Single Cell Proteomics Analysis with Nanodroplet Sample Processing, Multiplex TMT labeling, and Ultra-Sensitive LC-MS

Khatereh Motamedchaboki1, Maowei Dou1, Yongzheng Cong2, Romain Huguet1, Aaron M Robitaille1, Yufeng Shen3, Geremy Clair,4 Charles Ansong,4 Daniel Lopez-Ferrer1, Ryan T. Kelly2,4, and Ying Zhu4 Hupo 2019Understanding heterogeneity at single cell level...

Getting Connected Guide: Orbitrap Tribrid Series

This guide describes how to install the MS system in your laboratory and connect any external liquid chromatography (LC) devices. External devices include those that are controlled from or are independent of Thermo Scientific mass spectrometry applic...

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