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Knowledge Base Articles

Pushing the leading edge in protein analysis: Thermo Scientific Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer

BrochureUnderstanding biomolecules as drug targets, disease markers, and therapeutic agents demands highly sensitive analysis of complex biological samples, without sacrificing robustness and speed. The Thermo Scientific™ Q Exactive™ HF-X hybrid quad...

Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer - The Most Powerful Instrument Designed to Advance Your Scientific Pursuits

Orbitrap Fusion Lumos MS BrochurePUSHING NEW FRONTIERS IN SCIENCE Breakthroughs in science rely on great scientists making rapid progress answering challenging questions. “How does lipid metabolism affect cancer?” “How do non-cancerous cells mutate?”...

Single-Laboratory Validation Study of a Method for Screening and Identification of Phosphodiesterase Type 5 Inhibitors in Dietary Ingredients and Supplements Using Liquid Chromatography/Quadrupole-Orbital Ion Trap Mass Spectrometry: First Action 2015.12.

Vaclavik L, Schmitz JR, Halbardier JF, Mastovska KVaclavik et al.: Journal of AOAC International Vol. 99, No. 1, 2016A single-laboratory validation study of a method for screening and identification of phosphodiesterase type 5 (PDE5) inhibitors in di...

TCM & Natural Products

The use of natural materials to treat illness has a long history. Natural products and traditional Chinese medicines have been pursued across the world, often as a parallel course to other drug discovery endeavors. The complex nature of plant and ani...

Workflows_Pharma_TCM(1).jpg MWorkflows_SP_pharma_TCM.jpg MWorkflows_MS_Pharma_TCM.png MWorkflows_DA_Pharma_TCM.jpg

Rapid qualitative analysis of phthalates added to food and nutraceutical products by direct analysis in real time/orbitrap mass spectrometry

Self RL, Wu W. Food Control Volume 25, Issue 1, May 2012, 13-16.A recent food safety issue involves the contamination of a broad range of food and nutraceutical products from Taiwan with industrial plasticizers. Among the suspected contaminants are s...

Isolation and structural elucidation of flibanserin as an adulterant in a health supplement used for female sexual performance enhancement

Low MY, Li L, Ge X, Kee CL, Koh HL.J Pharm Biomed Anal. 2012 Jan 5;57:104-8. A health supplement used for female sexual performance enhancement was sent to Health Sciences Authority of Singapore for testing. An unknown compound was detected and isola...

CID of singly charged antioxidants applied in lubricants by means of a 3D ion trap and a linear ion trap–Orbitrap mass spectrometer

Kassler A, Pittenauer E, Doerr N, Allmaier G.J Mass Spectrom. 2011 Jun;46(6):517-28. The aim of this study was to investigate the fragmentation behavior induced by low-energy collision-induced dissociation (LE-CID) of four selected antioxidants appli...

An integrated high resolution mass spectrometric and informatics approach for the rapid identification of phenolics in plant extract

Aldini G, Regazzoni L, Pedretti A, Carini M, Cho SM, Park KM, Yeum KJ.J Chromatogr A. 2011 May 20;1218(20):2856-64.An integrated approach based on high resolution MS analysis (orbitrap), database (db) searching and MS/MS fragmentation prediction for ...

Qualitative and quantitative characterization of chemical constituents in Xin-Ke-Shu preparations by liquid chromatography coupled with a LTQ Orbitrap mass spectrometer

Peng JB, Jia HM, Liu YT, Zhang HW, Dong S, Zou ZM.J Pharm Biomed Anal. 2011 Jul 15;55(5):984-95. Xin-Ke-Shu (XKS), a traditional Chinese medicine (TCM) preparation containing five herbal medicines, has been commonly used for the treatment of coronary...

Rapid screening for cyclo-dopa and diketopiperazine alkaloids in crude extracts of Portulaca oleracea L. using liquid chromatography/tandem mass spectrometry

Xing J, Yang Z, Lv B, Xiang L.Rapid Commun Mass Spectrom. 2008 May;22(9):1415-22.A simple and rapid qualitative liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed and validated for screening cyclo-dopa and diketopiperazine...

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