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Knowledge Base Articles

A robust mass spectrometer for precision medicine – the Orbitrap Exploris 240 mass spectrometer for large-scale plasma protein profiling

Michelle L Dubuke1 , Sitara Chauhan1 , Sarah Trusiak1 , and Emily I. Chen1APPLICATION NOTE 65952To demonstrate the reliability and robustness of the Thermo Scientific™ Orbitrap Exploris™ 240 mass spectrometer for large-scale, untargeted plasma protei...

Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping

Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. JosephsAPPLICATION NOTE 72511To perform complete characterization of the lysine-linked antibody drug conjugate (ADC) trastuzumab emtansine using both intac...

Untargeted Metabolic Profiling of Oral Cancer Cells Using Capillary Ion Chromatography Coupled with an Orbitrap Mass Spectrometer

Terri Christison1 and Junhua Wang2Demonstrate the resolution and sensitivity provided by capillary ion chromatography (IC) coupled with high-resolution, accurate-mass (HRAM) Orbitrap mass-analyzer-based detection when applied to untargeted profiling ...

Results of Using Re-washed Vials and Closures

This note shows that this cleaning is causing both physical damage to the glass vials and is also ineffective at removing contamination from the vial surface. This contamination is unpredictable and produces interference peaks in both LC and GC chrom...

Ultra high resolution linear ion trap Orbitrap mass spectrometer (Orbitrap Elite) facilitates top down LC MS/MS and versatile peptide fragmentation modes

Michalski A, Damoc E, Lange O, Denisov E, Nolting D, Müller M, Viner R, Schwartz J, Remes P, Belford M, Dunyach JJ, Cox J, Horning S, Mann M, Makarov A.Mol Cell Proteomics. 2012 Mar;11(3):O111.013698.Although only a few years old, the combination of ...

Elemental formula annotation of polar and lipophilic metabolites using 13C, 15N and 34S isotope labelling, in combination with high-resolution mass spectrometry

Giavalisco P, Li Y, Matthes A, Eckhardt A, Hubberten HM, Hesse H, Segu S, Hummel J, Köhl K, Willmitzer L.Plant J. 2011 Oct;68(2):364-76. The unbiased and comprehensive analysis of metabolites in any organism presents a major challenge if proper peak ...

Degradation of poly(butyl methacrylate) model compounds studied via high-resolution electrospray ionization mass spectrometry

Soeriyadi AH, Bennet F, Whittaker MR, Barker PJ, Barner-Kowollik C, Davis TP.Journal of Polymer Science Part A: Polymer Chemistry. 2011 Feb 15;49(4):848-6This study investigates the degradation behavior of poly(n-butyl methacrylate) (p(nBMA)), poly(t...

Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis

t'Kindt R, Jankevics A, Scheltema RA, Zheng L, Watson DG, Dujardin JC, Breitling R, Coombs GH, Decuypere S.Anal Bioanal Chem. 2010 Nov;398(5):2059-69.Comparative metabolomics of Leishmania species requires the simultaneous identification and quantifi...

Mass spectrometry strategies in metabolomics

Lei Z, Huhman DV, Sumner LW.J Biol Chem. 2011 Jul 22;286(29):25435-42.Mass spectrometry (MS) has evolved as a critical component in metabolomics which seeks to answer biological questions through large-scale qualitative and quantitative analyses of t...

A quantitative atlas of mitotic phosphorylation

Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP.Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7.he eukaryotic cell division cycle is characterized by a sequence of orderly and highly regulated events resulting in ...

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