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SelectScience Interview: Mass Spectrometry Inventor, Alexander Makarov, Explains How State-of-the-Art MS is Being Utilized in World Leading Anti-Doping Laboratories

Alexander MakarovSelectScience InterviewThe Hong Kong Jockey Club is one of the largest and most well respected flat racing organizations in the world. The Club has a world class drug-testing facility, on site at the Sha Tin Racecourse. This internat...

Performing nanoLC doesn’t have to be wicked hard

Southwick KiOrbi 2014 Tips on key practices that will help make you successful with nLC. Information on nLC and column maintenance as well as suggestions to increase the robustness of nLC.http://iconference.adobeconnect.com/p6m9b0mgxed/Thermo Fisher ...

Proteomic Analysis Reveals Expression Differences in Escherichia coli Strains Associated with Persistent Versus Transient Mastitis

Lippolis JD, Brunelle BW, Reinhardt TA, Sacco RE, Nonnecke BJ, Dogan B, Simpson K, Schukken YH.ASMS 2013 PosterEscherichia coli is a leading cause of bacterial mastitis in dairy cattle. Typically this infection is transient in nature, causing an infe...

Maximize glycan structural information

Thermo Scientific Guide to Glycan AnalysisGlycosylation is one of the most important post-translational modifications of eukaryotic cell proteins. Glycan-modified proteins are involved in a wide range of biological and physiological processes includi...

Evaluation and Optimization of Mass Spectrometric Settings during Data-dependent Acquisition Mode: Focus on LTQ-Orbitrap Mass Analyzers

Kalli A, Smith GT, Sweredoski MJ, Hess S.J Proteome Res. 2013 Jul 5;12(7):3071-86.Mass-spectrometry-based proteomics has evolved as the preferred method for the analysis of complex proteomes. Undoubtedly, recent advances in mass spectrometry instrume...

Fast photochemical oxidation of proteins for comparing structures of protein-ligand complexes: the calmodulin-peptide model system

Zhang H, Gau BC, Jones LM, Vidavsky I, Gross ML.Anal Chem. 2011 Jan 1;83(1):311-8.Fast photochemical oxidation of proteins (FPOP) is a mass spectrometry-based protein footprinting method that modifies proteins on the microsecond time scale. Highly re...

Identification of the unknown transformation products derived from clarithromycin and carbamazepine using liquid chromatography/high-resolution mass spectrometry

Calza P, Medana C, Padovano E, Giancotti V, Baiocchi C.Rapid Commun Mass Spectrom. 2012 Aug 15;26(15):1687-704.RATIONALE: A comprehensive study of the environmental fate of pollutants is more and more required, above all on new contaminants, i.e. pha...

Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS

Meyer MR, Du P, Schuster F, Maurer HH.J Mass Spectrom. 2010 Dec;45(12):1426-42.Since the late 1990s, many derivatives of the α-pyrrolidinophenone (PPP) drug class appeared on the drugs of abuse market. The latest compound was described in 2009 to be ...

Investigation of drugs of abuse and relevant metabolites in Dutch sewage water by liquid chromatography coupled to high resolution mass spectrometry

Bijlsma L, Emke E, Hernández F, de Voogt P.Chemosphere. 2012 Nov;89(11):1399-406.An extensive study on the presence of illicit drugs and pharmaceuticals with potential for abuse in sewage waters was made for the first time in the Netherlands. A total...

Identification of transformation products of organic contaminants in natural waters by computer-aided prediction and high-resolution mass spectrometry

Kern S, Fenner K, Singer HP, Schwarzenbach RP, Hollender J.Environ Sci Technol. 2009 Sep 15;43(18):7039-46.Transformation products (TPs) of organic contaminants in aquatic environments are still rarely considered in water quality and chemical risk as...

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