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Knowledge Base Articles

SelectScience Interview: Mass Spectrometry Inventor, Alexander Makarov, Explains How State-of-the-Art MS is Being Utilized in World Leading Anti-Doping Laboratories

Alexander MakarovSelectScience InterviewThe Hong Kong Jockey Club is one of the largest and most well respected flat racing organizations in the world. The Club has a world class drug-testing facility, on site at the Sha Tin Racecourse. This internat...

Performing nanoLC doesn’t have to be wicked hard

Southwick KiOrbi 2014 Tips on key practices that will help make you successful with nLC. Information on nLC and column maintenance as well as suggestions to increase the robustness of nLC.http://iconference.adobeconnect.com/p6m9b0mgxed/Thermo Fisher ...

Mass spectrometry imaging with high resolution in mass and space (HR(2) MSI) for reliable investigation of drug compound distributions on the cellular level.

Römpp A, Guenther S, Takats Z, Spengler BAnal Bioanal Chem. 2011 Jul;401(1):65-73.Mass spectrometry (MS) imaging is a versatile method to analyze the spatial distribution of analytes in tissue sections. It provides unique features for the analysis of...

Maximize glycan structural information

Thermo Scientific Guide to Glycan AnalysisGlycosylation is one of the most important post-translational modifications of eukaryotic cell proteins. Glycan-modified proteins are involved in a wide range of biological and physiological processes includi...

Metabonomics of newborn screening dried blood spot samples: a novel approach in the screening and diagnostics of inborn errors of metabolism

Dénes J, Szabó E, Robinette SL, Szatmári I, Szőnyi L, Kreuder JG, Rauterberg EW, Takáts Z.Anal Chem. 2012 Nov 20;84(22):10113-20.A novel, single stage high resolution mass spectrometry-based method is presented for the population level screening of i...

High-resolution mass spectrometry method for the detection, characterization and quantitation of pharmaceuticals in water

Pinhancos R, Maass S, Ramanathan DM.J Mass Spectrom. 2011 Nov;46(11):1175-81.The presence of pharmaceuticals in drinking water is an emerging environmental concern. In most environmental testing laboratories, LC-MS/MS assays based on selected reactio...

Metabolism of Vertebrate Amino Sugars with N-glycolyl Groups: Incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine

Bergfeld AK, Pearce OM, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A.J Biol Chem. 2012 Aug 17;287(34):28898-916.The outermost positions of mammalian cell-surface glycans are predominantly occupied by the sialic acids N-acetylneurami...

Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-orbitrap mass spectrometer

Roux A, Xu Y, Heilier JF, Olivier MF, Ezan E, Tabet JC, Junot C.Anal Chem. 2012 Aug 7;84(15):6429-37.Metabolic profiles of biofluids obtained by atmospheric pressure ionization mass spectrometry-based technologies contain hundreds to thousands of fea...

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