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Knowledge Base Articles

Increased throughput and coverage for the annotation of saponins using a structure-based MSn approach on an Orbitrap Tribrid mass spectrometer

Reiko Kiyonami, Caroline Ding, Seema Sharma, and Andreas HuhmerAPPLICATION NOTE 73236To develop a structure-based MSn workflow to collect more structurally relevant fragment ion information for the annotation of saponins from traditional Chinese medi...

Detecting low abundant endogenous cardiac steroids from biological fluids using a structure-based MSn approach on an Orbitrap Tribrid mass spectrometer

Reiko Kiyonami1 , Michael G. Harrington2 , Alfred N. Fonteh2 , Roger G. Biringer3 , and Andreas F. Huhmer1APPLICATION NOTE 73235To develop an unbiased discovery-to-targeted-verification approach to detect low abundant endogenous cardiac steroids from...

Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping

Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. JosephsAPPLICATION NOTE 72511To perform complete characterization of the lysine-linked antibody drug conjugate (ADC) trastuzumab emtansine using both intac...

High-throughput untargeted screening of veterinary drug residues and metabolites in tilapia using high resolution orbitrap mass spectrometry

Wei Jia a, b *, Xiaogang Chu a, b, James Chang c, Perry G. Wang d, Ying Chen b, Feng Zhang bW. Jia, X. Chu, J. Chang, P.G. Wang, Y. Chen, F. Zhang, High-throughput untargeted screening of veterinary drug residues and metabolites in tilapia using high...

Development and Validation of a Qualitative Method for Target Screening of 448 Pesticide Residues in Fruits and Vegetables Using UHPLC/ESI Q‑Orbitrap Based on Data-Independent Acquisition and Compound Database

Jian Wang, Willis Chow, James Chang, Jon W. WongJ Agric Food Chem. 2017 Jan 18;65(2):473-493. doi: 10.1021/acs.jafc.6b05034. Epub 2017 Jan 5.A semiautomated qualitative method for target screening of 448 pesticide residues in fruits and vegetables wa...

Beverage Application Reference Brochure

Confidence in every drop. Beverage Analysis. From routine analysis to high-end detection, you know the answers can affect so much more than your product; they can make or break your brand. This brochure will help you understand what you WANT to look ...

EPA Method 543 – Quantitation of Organic Pesticides in Drinking Water Using Online Pre-concentration/Solid Phase Extraction and Tandem Mass Spectrometry

To assist in the validation of a new EPA method for the analysis of organicpesticides in drinking water. This method utilizes large volume injections foronline preconcentration and eliminates offline solid phase extraction (SPE).

A Sensitive and Efficient Method to Analyze THC and THCCOOH in Oral Fluid Using LC-MS/MS in Forensic Toxicology Laboratories

In this study, we developed a sensitive and efficient method for simultaneous determination of THC and THCCOOH in OF. Both analytes were extracted using a simple and fast SPE method without pre-conditioning, evaporation, or reconstitution. THCCOOH wa...

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