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Knowledge Base Articles

Increased confidence of insect lipidome annotation from high-resolution Orbitrap LC/MSn analysis and LipidSearch software

David Peake1, Reiko Kiyonami1, Yasuto Yokoi2, Yelena Aldefinskaya3, Jeff Gilbert3, and Daniel Gachotte3APPLICATION NOTE 72942• Demonstrate the utility of LC/MS and data-dependent MSn acquisition for simultaneous lipid profiling and more complete lipi...

Evaluation of the AcquireX workflow for deciphering lipidome analysis of neutral lipids from whole insects using chromatography-based methods with high-resolution Orbitrap MSn

Daniel Gachotte1, Yelena Adelfinskaya1, Jeffrey Gilbert1, Jonathan Robeson2, Adane Kassa2, Reiko Kiyonami3, Yasuto Yokoi4 and David Peake3 ASMS 2019 PosterInsect lipids are highly structurally diverse species that perform many important functions inc...

Improved Lipid Annotation Depth using Automatically Generated Inclusion and Exclusion Lists on an Orbitrap-based Mass Spectrometer

Sven Hackbusch, David A. Peake, Reiko KiyonamiASMS 2019 PosterPurpose: To demonstrate the application of an automated background-exclusion and compound-inclusion generation workflow for global lipidome profiling, leading to a greater number and great...

Grant application resource: Thermo Scientific Orbitrap ID-X Tribrid mass spectrometer for metabolomics, lipidomics and structural elucidation

WHITE PAPER 65364This document is intended to provide conclusive reasons to justify upgrading from a Thermo Scientific™ Q Exactive™ mass spectrometer series or earlier generation of Thermo Scientific™ Orbitrap™ Hybrid™ mass spectrometer series to a T...

Increased Depth and Confidence of Insect Lipidome Analysis using Chromatography Based Methods with High-resolution Orbitrap MSn

Daniel Gachotte1, Yelena Adelfinskaya1, Jeffrey Gilbert1, Vimbai Chikwana1, Sek Yee Tan1, Jonathan Robeson2, Adane Kassa2, Ken Narva1, Reiko Kiyonami3, David Peake3 and Yasuto Yokoi4 ASMS 2018Insect lipids are highly structurally diverse species that...

LipidSearch 5.0: A New Software for Processing Data from Direct Infusion and LC-MS High Resolution Mass Spectrometry Based Lipidomics Workflows

David A Peake1, Yasuto Yokoi2, Yukihiro Fukamachi2, Reiko Kiyonami1, Elena Sokol1 and Gavin Reid3ASMS 2017 Poster1 Thermo Fisher Scientific, San Jose, CA, USA 2 Mitsui Knowledge Industry Co., Tokyo, Japan 3 University of Melbourne, Parkville, Victori...

High Throughput Lipid Identification and Quantification Using a Directed HRAM LC-MS-MS approach on a Modified Quadrupole-Orbitrap Mass Spectrometer

Reiko Kiyonami, David A. Peake and Andreas HuhmerASMS 2017 PosterPurpose: Develop a robust and reproducible HPLC MS-MS method which enables untargeted lipid identification and targeted screening of thousands major lipid molecule for getting estimated...

Pushing the leading edge in protein analysis: Thermo Scientific Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer

BrochureUnderstanding biomolecules as drug targets, disease markers, and therapeutic agents demands highly sensitive analysis of complex biological samples, without sacrificing robustness and speed. The Thermo Scientific™ Q Exactive™ HF-X hybrid quad...

Identification of Phospholipid Species Implicated in Dementia by Untargeted High Resolution LC/MS and Data Dependent MS/MS

David A Peake1, Mandy Bowman1, Reiko Kiyonami1 and Danni Li2Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Recently, Mapstone et al.1 reported a panel of plasma phospholipids (Table 1) that predicted cognitively normal adul...

Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer - The Most Powerful Instrument Designed to Advance Your Scientific Pursuits

Orbitrap Fusion Lumos MS BrochurePUSHING NEW FRONTIERS IN SCIENCE Breakthroughs in science rely on great scientists making rapid progress answering challenging questions. “How does lipid metabolism affect cancer?” “How do non-cancerous cells mutate?”...

Facilitate Biomarker Discovery Using Integrated “Omics” Differential Analysis with High Resolution Accurate LC/MS Approach

Reiko Kiyonami1, Sergei Snovida2, Devin Drew1, Rosa Viner1 , Julian Saba1, David Peake1, Andreas Huhmer1, Ken Miller1Application of “Omics” technologies to unbiased clinical biomarker discovery research of various diseases is emerging because compreh...

Software for Integrated Processing and Analysis in Direct Infusion Ultra-High Resolution/Accurate Mass Spectrometry Based ‘Top-Down’ Lipidomics Workflows

1Yasuto Yokoi, 1Yukihiro Fukamachi, 2David Peake, 2Reiko Kiyonami, 3Yepy Rustam, 3Eileen Ryan and 3Gavin E. ReidASMS 2016 PosterHere, we describe the key features and demonstrate the performance of LipidSearchTM 5.0α (Figure 3), a new software packag...

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