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Knowledge Base Articles

Pushing the leading edge in protein analysis: Thermo Scientific Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer

BrochureUnderstanding biomolecules as drug targets, disease markers, and therapeutic agents demands highly sensitive analysis of complex biological samples, without sacrificing robustness and speed. The Thermo Scientific™ Q Exactive™ HF-X hybrid quad...

Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer - The Most Powerful Instrument Designed to Advance Your Scientific Pursuits

Orbitrap Fusion Lumos MS BrochurePUSHING NEW FRONTIERS IN SCIENCE Breakthroughs in science rely on great scientists making rapid progress answering challenging questions. “How does lipid metabolism affect cancer?” “How do non-cancerous cells mutate?”...

Higher-order structural interrogation of antibodies using middle-down hydrogen/deuterium exchange mass spectrometry

Jingxi Pan,a Suping Zhang,b Albert Choua and Christoph H. Borchers*acChem. Sci., 2016, Advance Article DOI: 10.1039/C5SC03420EAlthough X-ray crystallography is the “gold standard” method for protein higher-order structure analysis, the challenges of ...

Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini

Panchenko T, Sorensen TC, Woodcock CL, Kan ZY, Wood S, Resch MG, Luger K, Englander SW, Hansen JC, Black BE.Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16588-93.Centromere protein A (CENP-A) is a histone H3 variant that marks centromere location on ...

Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer

Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Garcia-Ordonez RD, Pascal BD, Burris TP, Dodge JA, Griffin PR.Structure. 2010 Oct 13;18(10):1332-41.Regulation of nuclear receptor (NR) activity is driven by alterations in the conformational dynamics of ...

Online, High-Pressure Digestion System for Protein Characterization by Hydrogen/Deuterium Exchange and Mass Spectrometry

Jones LM, Zhang H, Vidavsky I, Gross ML.Anal Chem. 2010 Feb 15;82(4):1171-4.The rapid and complete digestion of proteins is important when protein characterization by hydrogen-deuterium exchange (HDX) is coupled with mass spectrometry. We developed a...

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