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Knowledge Base Articles

Pushing the leading edge in protein analysis: Thermo Scientific Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer

BrochureUnderstanding biomolecules as drug targets, disease markers, and therapeutic agents demands highly sensitive analysis of complex biological samples, without sacrificing robustness and speed. The Thermo Scientific™ Q Exactive™ HF-X hybrid quad...

Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer - The Most Powerful Instrument Designed to Advance Your Scientific Pursuits

Orbitrap Fusion Lumos MS BrochurePUSHING NEW FRONTIERS IN SCIENCE Breakthroughs in science rely on great scientists making rapid progress answering challenging questions. “How does lipid metabolism affect cancer?” “How do non-cancerous cells mutate?”...

Development of Bioinformatics Support for High Throughput Isomeric Separation and the Structural Identification of Glycans by LC-MS

Ningombam Sanjib Meitei1, Arun Apte2, Udayanath Aich3, Julian Saba4The separation of glycans by chromatography prior to MS analysis can reduce sample complexity, minimize ion suppression, and increase dynamic range and separation of structural isomer...

Integrated LC/MS Workflow for the Analysis of Labeled and Native N-Glycans from Proteins Using a Novel Mixed-Mode Column and a Q Exactive Mass Spectrometer

Aich U, Saba J, Viner R, Liu X, Rao S, Agroskin Y, Huhmer A, Pohl C. Application Note 595This application note presents a step-by-step method for the release, labeling, separation, and structural elucidation of N-glycans from proteins by LC-MS/MS.The...

Maximize glycan structural information

Thermo Scientific Guide to Glycan AnalysisGlycosylation is one of the most important post-translational modifications of eukaryotic cell proteins. Glycan-modified proteins are involved in a wide range of biological and physiological processes includi...

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