Scientific Library
Access peer-reviewed scientific papers, application notes, technical guides, specification sheets, scientific posters, brochures, product support bulletins and so much more.
cancel
Showing results for 
Search instead for 
Did you mean: 

Knowledge Base Articles

Pushing the leading edge in protein analysis: Thermo Scientific Q Exactive HF-X hybrid quadrupole-Orbitrap mass spectrometer

BrochureUnderstanding biomolecules as drug targets, disease markers, and therapeutic agents demands highly sensitive analysis of complex biological samples, without sacrificing robustness and speed. The Thermo Scientific™ Q Exactive™ HF-X hybrid quad...

Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer - The Most Powerful Instrument Designed to Advance Your Scientific Pursuits

Orbitrap Fusion Lumos MS BrochurePUSHING NEW FRONTIERS IN SCIENCE Breakthroughs in science rely on great scientists making rapid progress answering challenging questions. “How does lipid metabolism affect cancer?” “How do non-cancerous cells mutate?”...

Full Characterization of Heterogeneous Antibody Samples Under Denaturing and Native Conditions on a Hybrid Quadrupole-Orbitrap Mass Spectrometer

Scheffler K, Damoc E, Sutton J, Bailey A, Houel S, Josephs J.ASMS 2016 PosterHere we cover the three major workflows for characterization of biopharmaceuticals on one single instrument LC-MS platform using single and mixed antibody samples: 1)intact ...

Complete Characterization of a Cysteine-linked Antibody-Drug Conjugate Performed on a Hybrid Quadrupole-Orbitrap Mass Spectrometer with High Mass Range

Bailey A, Damoc E, Houel S, Scheffler K, Josephs J. ASMS 2016 PosterWe have modified the instrument control software of a benchtop quadrupole-Orbitrap mass spectrometer to add native MS capability. In this study we demonstrate complete characterizati...

A Journey in Biotherapeutic Peptide Mapping

Cheng G C. https://www.youtube.com/watch?v=boL6vZ4s4hkLearn about how the latest chromatography, mass spectrometry and software are accelerating confident decision making at Alexion Pharmaceuticals, Inc. Discover how this biopharmaceutical company, f...

Analysis of monoclonal antibody sequence and post-translational modifications by time-controlled proteolysis and tandem mass spectrometry

Lichao Zhang1, A. Michelle English1, Dina L. Bai1, Scott A. Ugrin1, Jeffrey Shabanowitz1, Mark M. Ross1, Donald F. Hunt1,2,* and Wei-Han Wang1Mol Cell Proteomics. 2015 Nov 29. pii: mcp.O115.056721Methodology for sequence analysis of ~150 kDa monoclon...

A “Universal” data-dependent mass spectrometry method that eliminates time-consuming method optimization for achieving maximal identifications from each sample

Eliuk S, Soltero N, Remes P, Scheffler K, Senko M, Zabrouskov V.2014 Poster and method for software version 1.1 and 1.2 SP1***Updated 4/15/15 with new instrument method for new software release. Developing optimal methods for samples, particularly th...

Comprehensive Sequence and Post-translational Modifications Analysis of Monoclonal Antibody by Flash Digest and LC-High Resolution MS

Wang HJ, O'Grady J, Horn D, Hao Z, Meyer K, Josephs J.ASMS 2014 PosterPurpose: To develop a workflow for fast and comprehensive characterization of peptide sequence, identification and relative quantitation of post-translational modifications (PTMs) ...

Rapid identification of low level glycation sites in recombinant antibodies by isotopic labeling with 13C6-reducing sugars

Zhang J, Zhang T, Jiang L, Hewitt D, Huang Y, Kao YH, Katta V.Anal Chem. 2012 Mar 6;84(5):2313-20.Recombinant antibodies exhibit low levels of glycation from exposure to reducing sugars during production. As the glycation sites are typically distribu...

Application of liquid chromatography-mass spectrometry in the study of metabolic profiling of cirrhosis in different grades

Du Z, Zhang L, Liu S.Se Pu. 2011 Apr;29(4):314-9.The metabolic profiles were obtained by high performance liquid chromatography combined with a LTQ Orbitrap XL mass spectrometer (HPLC-LTQ Orbitrap XL MS) platform to analyze serum specimens from the p...

Top Contributors