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Knowledge Base Articles

A robust mass spectrometer for precision medicine – the Orbitrap Exploris 240 mass spectrometer for large-scale plasma protein profiling

Michelle L Dubuke1 , Sitara Chauhan1 , Sarah Trusiak1 , and Emily I. Chen1APPLICATION NOTE 65952To demonstrate the reliability and robustness of the Thermo Scientific™ Orbitrap Exploris™ 240 mass spectrometer for large-scale, untargeted plasma protei...

High purity aluminum analysis

High purity aluminum analysisJoachim HinrichsThermo Fisher Scientific, Bremen, GermanyAN30142This note describes the procedures and results for GD-MS analysis of high purity aluminum.GD-MS aluminum high purity metals ultra-trace analysis

Analysis of solar cell silicon

Analysis of solar cell siliconJoachim HinrichsThermo Fisher Scientific, Bremen, GermanyAN30164The Element GD Plus GD-MS is capable of determining impurities directly in the solar cell silicon at sub ppb concentration levels for many elements.GD-MS al...

High-throughput single cell proteomics analysis with nanodroplet sample processing, multiplex TMT labeling, and ultra-sensitive LC-MS

Khatereh Motamedchaboki1 , Maowei Dou1 , Yongzheng Cong2 , Romain Huguet1 , Aaron M Robitaille1 , Yufeng Shen3 , Geremy Clair4 ,Charles Ansong4 , Daniel Lopez-Ferrer1 , Ryan T. Kelly2,4, and Ying Zhu4APPLICATION NOTE 65714Understanding heterogeneity ...

Sampling the human population – ultra-highthroughput plasma protein profiling (uHTPPP) sample preparation for translational proteomics

Sarah Trusiak,1 Sergei Snovida,2 Bhavin Patel,2 Ryan Bomgarden,2 Emily I. Chen,1Present a robust, precise, and reproducible highthroughput sample preparation workflow for mass spectrometry-based large population cohort studies.1. Thermo Fisher Scient...

Standardized and scalable plasma protein quantitative profiling workflow using human blood based on a Thermo Scientific Q exactive platform

Jing Wang1; Sarah Trusiak1; Ryan D. Bomgarden2; Sergei Snovida2; Michelle Dubuke1, Emily I. Chen1APLICATION NOTE No. 73194To develop a high throughput plasma and serum proteomics analysis workflow for large population cohort studies that utilizes a s...

Standardized and scalable plasma protein quantitative profiling workflow using human blood based on a Thermo Scientific Q exactive platform

Jing Wang1; Sarah Trusiak1; Ryan D. Bomgarden2; Sergei Snovida2; Michelle Dubuke1, Emily I. Chen1APLICATION NOTE No. 73194To develop a high throughput plasma and serum proteomics analysis workflow for large population cohort studies that utilizes a s...

Increased throughput and coverage for the annotation of saponins using a structure-based MSn approach on an Orbitrap Tribrid mass spectrometer

Reiko Kiyonami, Caroline Ding, Seema Sharma, and Andreas HuhmerAPPLICATION NOTE 73236To develop a structure-based MSn workflow to collect more structurally relevant fragment ion information for the annotation of saponins from traditional Chinese medi...

Detecting low abundant endogenous cardiac steroids from biological fluids using a structure-based MSn approach on an Orbitrap Tribrid mass spectrometer

Reiko Kiyonami1 , Michael G. Harrington2 , Alfred N. Fonteh2 , Roger G. Biringer3 , and Andreas F. Huhmer1APPLICATION NOTE 73235To develop an unbiased discovery-to-targeted-verification approach to detect low abundant endogenous cardiac steroids from...

Improving battery performance

Improving battery performanceSascha Nowak (MEET, University Muenster, Germany) in cooperation with Thermo Fisher ScientificThermo Fisher Scientific, Bremen, GermanyCS30594To demonstrate the versatility of HR-ICP-MS in speciation HR-ICP-MS lithium ion...

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