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Knowledge Base Articles

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue associated with an instrument method including data dependent MS2 triggered MS2 acquisition using UVPD activation.

Orbitrap Tribrid Series 3.4 PatchAcquisition crash can be observed with an instrument method including data dependent MS2 triggered MS2 acquisition using UVPD activation.Thermo Fisher Scientific

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue associated with possible signal intensity fluctuation under specific acquisition conditions.

Orbitrap Tribrid Series 3.4 PatchThe fluctuation in signal intensity could be observed when performing DDA acquisition with precursor ions fragmented by resonance CID activation and with MS2 spectra acquired in Orbitrap and using Auto Mass Range sett...

A robust mass spectrometer for precision medicine – the Orbitrap Exploris 240 mass spectrometer for large-scale plasma protein profiling

Michelle L Dubuke1 , Sitara Chauhan1 , Sarah Trusiak1 , and Emily I. Chen1APPLICATION NOTE 65952To demonstrate the reliability and robustness of the Thermo Scientific™ Orbitrap Exploris™ 240 mass spectrometer for large-scale, untargeted plasma protei...

Orbitrap Tribrid Series 3.4 Patch: This patch works around a problem in which split peaks could be observed only after instrument bootup.

Orbitrap Tribrid Series 3.4 PatchAfter toggling instrument polarity or eFT state, or perhaps running the eFT calibration, the peak splitting goes away and does not return until the next instrument reset. This was traced to a problem with certain stag...

Orbitrap Tribrid Series 3.4 Patch: This patch addresses an issue where sometimes the Trap Resonance CID calibration doesn’t reliably pass.

Orbitrap Tribrid Series 3.4 PatchIn some instances, the coarse calibration adjustment, that is automatically done behind the scenes, could make the calibration more difficult to pass, while the calibration would pass fine if this coarse adjustment wa...

Multi-pathway signaling analysis using a synthetic phosphopeptide panel, standardized sample preparation kits and SureQuant internal standard targeted quantitation

Aaron S. Gajadhar1, Bhavin Patel2, Penny Jensen2, Sebastien Gallien3,4, Romain Huguet1, Kay Opperman2, John C Rogers2, Andreas Huhmer1, Daniel Lopez-Ferrer1 International Hupo 2020To develop a universal phosphopeptide enrichment and internal standard...

Extending Capabilities of Real-Time Database Search on the Orbitrap Eclipse Tribrid Mass Spectrometer for Multiplexed Proteomics

Yang Liu, William D. Barshop, Amirmansoor Hakimi, Jesse D. Canterbury, Romain Huguet, Rosa Viner International Hupo 2020To evaluate recent improvements to Real-Time Search for TMT SPS MS3 quantitation workflow including: 1) Close-out to prevent acqui...

Compound Discoverer 3.2 released

Compound Discoverer 3.2 has been released. New features include: Processing capability for GC-Orbitrap data Neutral loss searches Custom tags for annotating and filtering result table entries Support for importing structures from SDF files Support fo...

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