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irm-LC/MS: δ13C Analysis of Underivatized Amino Acids

Team TFS
Team TFS
irm-LC/MS: δ13C Analysis of Underivatized Amino Acids
Dieter Juchelka, Michael Krummen
Thermo Fisher Scientific, Bremen, Germany
Isotope ratio monitoring-LC/MS (irm-LC/MS) with the Thermo Scientific LC IsoLink allows determination of 13C/12C ratios of individual amino acids without derivatization, eliminating all of the possible errors, limitations, and time requirements of derivatization. For amino acids water is the best solvent; HPLC columns are available on which the separation of amino acids can be performed with an aqueous mobile phase. The LC IsoLink offers new access to 13C-tracer experiments which investigate amino acid and protein metabolism.
  • IRMS
  • HPLC
  • Carbon isotopes
  • Amino acids
Version history
Last update:
‎11-09-2021 03:48 AM
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