irm-LC/MS: δ13C Analysis of RNA
Barbara J. MacGregor (1), Adam Friedman (1), Dieter Juchelka (2)
1) Department of Marine Sciences, University of North Carolina, Chapel Hill, N.C. USA; 2) Thermo Fisher Scientific, Bremen, Germany
AN30055
With the development of the Thermo Scientific LC IsoLink interface, compounds can now be separated by HPLC and analyzed online for their individual 13C/12C ratios by isotope ratio MS. Here we report progress towards a method for HPLC separation of hydrolyzed RNA and determination of the carbon isotopic composition of the monomers.
- IRMS
- HPLC
- Carbon isotopes
- RNA
United States
