Isotope ratio monitoring-LC/MS (irm-LC/MS) with the Thermo Scientific LC IsoLink allows determination of 13C/12C ratios of individual amino acids without derivatization, eliminating all of the possible errors, limitations, and time requirements of derivatization. For amino acids water is the best solvent; HPLC columns are available on which the separation of amino acids can be performed with an aqueous mobile phase.
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