Toxicological Screening of 80 Drugs in Urine Using the High Resolution Exactive LC/MS Orbitrap Mass Spectrometer Coupled to Online Extraction and Turbulent Flow Chromatography

[Orbitrap_SciLib]

Shokati T, Simmons P, Davari B, Hoffman K, Byrd J, Kozack M, Zonderman J, Galinkin J, Christians U.
Slide Presentation
 A fast, sensitive, and reliable TurboFlow chromatography- Exactive Orbitrap high-resolution MS method for clinical drug screening as relevant for pain clinics was developed and validated.  LLODs for the majority of measured drugs were in a range of 5 ng/mL or below and LLOQs for most of tested drugs were less than 50 ng/ml. Based on our experience, the Exactive LC/MS platform is well-suited for the routine screening of legal and illegal drugs.


Thermo Fisher Scientific