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Toxicological Screening of 80 Drugs in Urine Using the High Resolution Exactive LC/MS Orbitrap Mass Spectrometer Coupled to Online Extraction and Turbulent Flow Chromatography

Reputable Mentor II
Reputable Mentor II
Shokati T, Simmons P, Davari B, Hoffman K, Byrd J, Kozack M, Zonderman J, Galinkin J, Christians U.
Slide Presentation
 A fast, sensitive, and reliable TurboFlow chromatography- Exactive Orbitrap high-resolution MS method for clinical drug screening as relevant for pain clinics was developed and validated.  LLODs for the majority of measured drugs were in a range of 5 ng/mL or below and LLOQs for most of tested drugs were less than 50 ng/ml. Based on our experience, the Exactive LC/MS platform is well-suited for the routine screening of legal and illegal drugs.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 08:53 AM
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