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Orbitrap_SciLib
Reputable Mentor II
Reputable Mentor II

GRANT APPLICATION RESOURCE
The Thermo Scientific™ Orbitrap™ Tribrid™ mass spectrometers are an essential tool for high-end life science research. Robustly designed, they come equipped with a quadrupole mass filter as well as an Orbitrap and linear ion trap mass analyzer. This hardware combination (exclusive to Orbitrap based mass spectrometers) provides superior analytical performance that enables multiple complex modes of analysis. This is due to the parallel isolation and detection mechanisms achievable with the Tribrid architecture, which was previously unattainable with Thermo Scientific™ Orbitrap hybrid MS. The most difficult analyses, including multiplexed quantitation of low-abundance peptides in complex matrices, characterization of positional isoforms of intact proteins, protein structure characterization using chemical crosslinking, and the deepest mining of challenging posttranslational modifications may be performed on the highly sensitive and versatile Thermo Scientific Orbitrap Fusion family of mass spectrometers. The Tribrid system can perform multiple fragmentation techniques that prove useful in terms of experimental flexibility for applications such as quantitation using isobaric tags, low level PTM analysis, data independent acquisition (DIA), and top-down proteomics. The Tribrid MS provides the highest resolution, heightened sensitivity, rapid acquisition rates, improved ETD fragmentation and exclusive analytical techniques (e.g. multiNotch SPS MS3) for accurate relative quantitation experiments. These instruments are intended to push the limits of detection, characterization and quantitation and are able to achieve proteome-wide coverage, by combining the versatility of a Tribrid system with the selectivity of Orbitrap technology, and the sensitivity and speed rivaling that of a triple quadrupole instrument.



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Last update:
‎10-15-2021 05:13 AM
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