New Opportunities for the Characterization of Intact Monoclonal Antibodies
Top-down and middle-down mass spectrometry offer important advantages for the characterization of biotherapeutics with complete molecular specificity.
Attaining comprehensive sequence coverage required to confidently verify primary sequence or map post-translational modifications can be challenging.
The Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ mass spectrometer with UVPD allows for improved characterization of antibodies by generating
backbone fragments that complement those obtained with electron and collisional-mediated ion activations.
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