on 05-25-201710:17 AM - edited on 10-15-202111:50 AM by AnalyteGuru
New Opportunities for the Characterization of Intact Monoclonal Antibodies
Top-down and middle-down mass spectrometry offer important advantages for the characterization of biotherapeutics with complete molecular specificity.
Attaining comprehensive sequence coverage required to confidently verify primary sequence or map post-translational modifications can be challenging.
The Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ mass spectrometer with UVPD allows for improved characterization of antibodies by generating
backbone fragments that complement those obtained with electron and collisional-mediated ion activations.