While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-resolution accurate-mass Thermo Scientific™ Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures. Common targets include impurities in monoclonal antibodies, antibody-drug conjugates (ADC), PEG-ylated proteins, oligomerized protein-based drugs, glycoforms, and protein assemblies. At the same time, the Exactive Plus EMR MS retains all of the capabilities that make it the ultimate solution for screening peptides and small molecules.
Thermo Fisher Scientific