on 07-02-201203:29 AM - edited on 11-09-202101:33 AM by usermigration2
Literature Review Thermo Scientific Orbitrap technology has become an established platform for liquid chromatography mass spectrometry (LC/MS) analysis. The high resolving power, mass accuracy, and dynamic range of the OrbitrapTM mass analyzer allow rigorous characterization of complex mixtures. A mass spectrometer comprised of an atmospheric-pressure ion source and a standalone Orbitrap mass analyzer has been developed with performance characteristics well-suited for application areas such as exact-mass measurements of organic compounds; early drug discovery, metabolism and pharmacokinetics; general unknown screening; and multi-residue analysis (pesticides, mycotoxins, veterinary drugs). For all of these applications, high-resolution, accurate-mass (HR/AM) measurements together with high dynamic range are required for unequivocal results in full-scan MS mode.