on 07-28-201407:58 AM - edited on 10-15-202109:56 AM by Closed Account
There is considerable interest in botanical supplements due to their purported health benefits. Mangosteen (Garcinia mangostana L) is a tropical fruit that is indigenous to Southeast Asia, where it has been historically used to treat abdominal pain, diarrhea, dysentery, inflammation, wound infection, suppuration, and chronic ulcer. Recently mangosteen has been proposed as a homeopathic therapy in the treatment of Parkinson’s disease. Such therapeutic benefits have been mostly attributed to a unique family of compounds referred to as xanthones that are most abundant in the pericarp of the fruit.
The chromatographic analysis of the xanthones and other potentially important analytes contained in this supplement presents a huge challenge. Although reversed phase HPLC with UV detection is widely used for the analysis of xanthones, such methods lack analyte resolution and/or require exceedingly long analysis time. This application describes an improved method achieved on the Vanquish platform that provides enhanced throughput with better resolution and peak capacity.