Aaron O. Bailey and Jonathan L. Josephs
c&en whitepapers
Intact mass analysis is a key characterization step for any therapeutic protein of interest as a prospective biologic drug. This whitepaper describes the latest approaches for optimizing intact mass analysis using separations-coupled MS.
The whitepaper describes the latest advances in methods, hardware, and software for intact mass analysis. It describes how these advances could be combined to further push the boundaries for intact mass analysis for complex heterogeneous biologic samples.
Key Learning Objectives
The principles of intact mass analysis for therapeutic protein characterization
The latest advances in separations and mass spectrometry hardware
New methods to optimize hardware performance
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