on 06-05-201612:12 PM - edited on 10-15-202110:20 AM by AnalyteGuru
Eiler J, Dallas B, Chimiak E, Schwieters J, Juchelka D, Makarov A, Griep-Raming J. ASMS 2016 Poster The distribution of rare isotopes (D, 13C, 15N, etc.) at molecular scales — site‐specific effects and/or multiple substitutions, or ‘clumping’ — offers many potential tools in environmental chemistry, geochemistry, biochemistry and other disciplines. Existing technologies for observing molecular‐scale isotopic structures (NMR, sector mass spectrometry, infrared spectroscopy) enable only a few such measurements, with limits on sample types and sizes. We present the results of an experiment to develop the Thermo Scientific Q Exactive GC Orbitrap™ instrument— an Orbitrap Fourier transform mass spectrometer — as a generalized tool for precise, accurate, rapid and sensitive measurements of molecular isotopic structures. Results to‐date indicate this technology can achieve uncertainties in the range of 0.1‐1 ‰ (part per thousand, relative, in abundance ratio) for many isotopic species, analytes and sample sizes, and
is rapid enough to measure ~10‐100 isotopic constraints on one compound.
Division of Geological and Planetary Sciences
Thermo Fisher Scientific