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Marx V.
Nat Methods. 2012 Dec 27;10:19-22.
Understanding disease-related changes, for example, calls for reliable, quantitative ways of assessing protein levels, and mass spectrometers are instruments able to nail that task. But the data from so-called discovery proteomics experiments in which mass spectrometry is used to identify a large number of proteins in a sample are not always useful to biologists. Enter targeted proteomics, in which the analysis focuses on a subset of proteins of interest in a sample—an approach that has been steadily gaining traction over the last few years.

http://www.nature.com/nmeth/journal/v10/n1/pdf/nmeth.2285.pdf
Nature Methods
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