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Systematic Evaluation of Ultrahigh Resolution MS Instrument Parameters to Optimize Top-Down Analysis

Reputable Mentor II
Reputable Mentor II
Zeller M, Müller M, Damoc E, Denisov E, Makarov A, Nolting D, Eliuk S, Blethrow J, Specht A, Moehring T, Zabrouskov V.
ASMS 2013 Poster Note
Purpose: Evaluation of instrument parameters to maximize protein top-down efficiency. Methods: HCD and ETD top-down MS/MS on a hybrid Thermo Scientific™ ion trap- Orbitrap™ mass spectrometer equipped with a compact, high-field Orbitrap mass analyzer. Results: Recommendations can be made for different instrument parameters such as protein precursor charge state, MSn target values, number of averaged spectra etc. towards LC timescale.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 06:23 AM
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