Zeller M, Müller M, Damoc E, Denisov E, Makarov A, Nolting D, Eliuk S, Blethrow J, Specht A, Moehring T, Zabrouskov V.
ASMS 2013 Poster Note
Purpose: Evaluation of instrument parameters to maximize protein top-down
efficiency.
Methods: HCD and ETD top-down MS/MS on a hybrid Thermo Scientific™ ion trap-
Orbitrap™ mass spectrometer equipped with a compact, high-field Orbitrap mass
analyzer.
Results: Recommendations can be made for different instrument parameters such
as protein precursor charge state, MSn target values, number of averaged spectra etc.
towards LC timescale.
Thermo Fisher Scientific
United States
