on 10-22-201206:57 AM - edited on 10-15-202111:23 AM by AnalyteGuru
Yan X, Akinnusi TO, Larsen AT, Auclair K. Org Biomol Chem. 2011 Mar 7;9(5):1538-46. A convenient synthesis of 4'-aminopantetheine from commercial D-pantethine is reported. The amino group was introduced by reductive amination in order to avoid substitution at a sterically congested position. Derivatives of 4'-aminopantetheine were also prepared to evaluate the effect of O-to-N substitution on inhibitors of the resistance-causing enzyme aminoglycoside N-6'-acetyltransferase. The biological results combined with docking studies indicate that in spite of its reported unusual flexibility and ability to adopt different folds, this enzyme is highly specific for AcCoA.