Showing results for 
Search instead for 
Did you mean: 

Structural characterizations of lipids A by MS/MS of doubly charged ions on a hybrid linear ion trap/Orbitrap mass spectrometer

Reputable Mentor II
Reputable Mentor II
Silipo A, De Castro C, Lanzetta R, Molinaro A, Parrilli M, Vago G, Sturiale L, Messina A, Garozzo D.
J Mass Spectrom. 2008 Apr;43(4):478-84.
Here, a new ‘one pot’ and fast approach is described, based on electrospray ionization (ESI) of negative ions by using a hybrid linear ion trap/orbitrap mass spectrometer (LTQ/orbitrap) for MS and MS/MS analysis. By this method the distribution of the primary and secondary acyl residues of the intact lipid A is inferred by analysis of the ESI spectra measured in positive and negative mode. The analysis of these data allows an unequivocal assignment of the fatty acid distribution. This methodology was successfully tested on two different lipid A with known structures, deriving from the Agrobacterium tumefaciens and Escherichia coli lipopolysaccharides (LPS). Copyright © 2007 John Wiley & Sons, Ltd.
Dipartimento di Chimica Organica e Biochimica, Universitá di Napoli Federico II, via Cynthia 4, 80126 Napoli, Italy.
Version history
Last update:
‎10-15-2021 11:33 AM
Updated by: