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Sheathless Capillary Electrophoresis Mass Spectrometry: Investigation Using High Resolution Accurate Mass MS for Metabolome Analysis

Reputable Mentor II
Reputable Mentor II
Wang J, Hudson JC, Conaway MP, Huang Y, Huhmer A.
ASMS 2013 Poster
Metabolomics is the comprehensive study of endogenous small molecule metabolites in biological samples. In the pharmaceutical context, understanding changes in the metabolome due to responses of potential drug candidates could accelerate drug discovery. Challenges in the analysis arise from the complexity or chemical diversity of the metabolites and the large amount of chemical background in the low mass range. In this study we investigate capillary electrophoresis (CE) and couple this separation technique to a fast, high resolution/accurate mass (HRAM) mass spectrometer for the analysis of charged species in plasma and urine. Plasma and urine samples are processed with automated, label free, differential analysis software (Thermo Scientific™ SIEVE™ 2.1 software) to extract the maximum number of significant components present.

Thermo Fisher Scientific
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Last update:
‎10-15-2021 11:27 AM
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