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Orbitrap_SciLib
Reputable Mentor II
Reputable Mentor II
Rajski L, Gómez Ramos M, Fernández-Alba AR

High resolution mass spectrometry is a technique which helps to overcome some typical limitations of triple quadrupole mass spectrometers. High resolution instruments provide accurate mass measurement. Spectrometers working in full scan mode can register unlimited number of compounds. This feature allows to perform non-target analysis and retrospective analysis. Hybrid instruments are also equipped in quadrupole mass filter and collision cell. Thanks to this it is possible to perform MS2 experiments. Amongst the several workflows which are available in QExactive™ very convenient is Full scan/Data Dependent-MS2. In this mode user defines list of target parent ions and retention time windows when the ions are expected. During the analysis data acquisition is carried out in full scan mode. However if any of the parent ions from the target list is detected in expected retention time window QExactive™ switch to MS2 mode, carries out one scan and goes back to full scan mode. Data obtained in full scan mode are used for quantitation whereas data from MS2 mode for identification. In Full scan/Targeted-MS2 is similar to Data Dependent however full scans and MS2 scans are carried out alternately.


European Union Reference Laboratory for Pesticide Residues in Fruit & Vegetables
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Last update:
‎10-15-2021 09:32 AM
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