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Reputable Mentor II
Reputable Mentor II
Khatereh Motamedchaboki1; Yang Liu1; Aaron Gajadhar1; Michelle Dubuke2; Emily Chen2; Tabiwang Arrey3; Julia Kraegenbring3; Alexander Harder3 and Daniel Lopez-Ferrer1
ASMS 2020
LC-MS-based proteomics analysis shown to be a powerful analytical tool for identification and quantification of thousands of proteins in complex biological samples. There has been a need for a robust mass spectrometry system that provide robustness needed to analyze 1000s of samples without compromising on coverage and quantitation performance and provide ease of use for any level of analytical expertise. Here we present a new quadrupole orbitrap hybrid mass spectrometer, Thermo Scientific™ Orbitrap Exploris™ 240 mass spectrometer, coupled to the High-Field Asymmetric Waveform Ion Mobility Spectrometry System (Thermo Scientific™ FAIMS Pro™ interface) as a robust workflow without compromising on performance. The peptide and protein identification performance in a data-dependent acquisition (DDA) mode on four different instruments across three different sites were evaluated for instrument readiness for large scale, cross laboratories studies. Untargeted label-free quantitation of peptides in different ratio and with mixed proteome showed great quantitation accuracy with the optimized label-free quantitation (LFQ) method template. In summary the new Orbitrap Exploris 240 mass spectrometer has shown great sensitivity and data reproducibility across multiple instrument with the optimized method templates for variety of proteomics applications available on this system providing versality and flexibility to navigate in between different proteomics application in a multidisciplinary proteomics laboratory with ease of use for different level of user's expertise.

1Thermo Fisher Scientific, San Jose, USA; 2Thermo Fisher Scientific, Cambridge, USA, 3Thermo Fisher Scientific, 3Thermo Fisher Scientific, Bremen, Germany
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Last update:
‎10-15-2021 11:19 AM
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