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Relative quantification using TMT11plex on a modified Q Exactive HF mass spectrometer

Reputable Mentor II
Reputable Mentor II
Tabiwang N. Arrey,1 Rosa Viner,2 Ryan D. Bomgarden,3 Eugen Damoc,1 Markus Kellmann,1 Thomas Moehring,1 and Alexander Harder1
ASMS 2017 Poster
Purpose: To benchmark a new hybrid quadrupole-Orbitrap™ mass spectrometer for relative quantification. Methods: HeLa cell lysate was labeled with Thermo Scientific™ TMT11plex™ reagents. Aliquots from all 11 channels were mixed in equimolar ratios and analyzed on the novel Thermo Scientific™ Q Exactive™ HF-X mass spectrometer. Results: Up to 18% more peptidesproteins were identified and quantified in a relative quantitative study using TMT11plex compared to the predecessor Thermo Scientific™ Q Exactive™ HF mass spectrometer.

1 Thermo Fisher Scientific (Bremen) GmbH, Hanna-Kunath-Str. 11, 28199 Bremen 2 Thermo Fisher Scientific, 355 River Oaks Parkway, San Jose, CA 95134 3 Thermo Fisher Scientific, 3747 N. Meridian Road, Rockford, IL 61101
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Last update:
‎10-15-2021 10:55 AM
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