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claudia-bouman
Team TFS
Team TFS
1) Department of Earth Sciences, University of Bristol, Wills Memorial Building, Bristol, BS8 4EU, UK, 2) Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK, 3) School of Engineering and Natural Sciences, University of Iceland, Hjarðarhagi 6, 107 Reykjavík, Iceland
Geochemical Transactions (2008), V9, doi: 10.1186/1467-4866-9-11
Re-partitioning of Cu and Zn isotopes by modified protein expression
Anette Büchl (1), Chris J Hawkesworth (1), K Vala Ragnarsdottir (1,3) and David R Brown (2)
Cu and Zn have naturally occurring non radioactive isotopes, and their isotopic systematics in a biological context are poorly understood. In this study we used double focussing mass spectroscopy to determine the ratios for these isotopes for the first time in mouse brain. The Cu and Zn isotope ratios for four strains of wild-type mice showed no significant difference (δ65Cu -0.12 to -0.78 permil; δ66Zn -0.23 to -0.48 permil). We also looked at how altering the expression of a single copper binding protein, the prion protein (PrP), alters the isotope ratios.
  • MC-ICPMS
  • Neptune
  • Cu-Zn isotopes
  • Protein
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