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claudia-bouman
Team TFS
Team TFS
1) Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, 85287, USA; 2) School of Earth and Space Exploration, Arizona State University, Tempe, AZ, 85287, USA; 3) Human Adaptation and Countermeasures Division, National Aeronautics and Space Administration, Houston, TX, 77058, USA
Proceedings of the National Academy of Science of the United States of America (2012), V109(25), pp9989–9994, doi:10.1073/pnas.1119587109
Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes
Jennifer L. L. Morgan (1,3), Joseph L. Skulan (2), Gwyneth W. Gordon (2), Stephen J. Romaniello (2) Scott M. Smith (3) and Ariel D. Anbara (2)
The ability to rapidly detect changes in bone mineral balance (BMB) would be of great value in the early diagnosis and evaluation of therapies for metabolic bone diseases such as osteoporosis and some cancers. However, measurements of BMB are hampered by difficulties with using biochemical markers to quantify the relative rates of bone resorption and formation and the need to wait months to years for altered BMB to produce changes in bone mineral density large enough to resolve by X-ray densitometry. We show here that, in humans, the natural abundances of Ca isotopes in urine change rapidly in response to changes in BMB. In a bed rest experiment, use of high-precision isotope ratio MS allowed the onset of bone loss to be detected in Ca isotope data after about 1 wk, long before bone mineral density has changed enough to be detectable with densitometry.
  • MC-ICPMS
  • Neptune
  • Ca isotopes
  • Osteopenia
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